Browsing Department of Brain and Cognitive Sciences by Title
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Browsing Department of Brain and Cognitive Sciences by Title
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(Massachusetts Institute of Technology, 2004)It has been assumed that Ca2+ influx of different duration and amplitude would generate different level of potentiation. The conventional protocols of generating LTP have been 1. tetanic stimulation of presynaptic cell, ...
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(Massachusetts Institute of Technology, 2001)Long term potentiation (LTP) of synaptic transmission at the CA3-CA1 hippocampal synapse is a model synaptic plasticity mechanism that may underlie hippocampal dependent learning and memory. Inhibition of post-synaptic ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2002)The ability to group stimuli into meaningful categories is a fundamental cognitive process though little is known its neuronal basis. To address this issue, we trained monkeys to perform a categorization task in which they ...
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Causal control of the thalamic reticular nucleus using optogenetic and novel chemogenetic approaches (Massachusetts Institute of Technology, 2016)Incoming sensory information from all modalities, with the exception of olfaction, synapses in the thalamus on the way to neocortex. This sensory relay is uniquely positioned to act as a gate, to determine which inputs ...
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(Massachusetts Institute of Technology, 2014)Neuroscientists hold widely divergent opinions on the behavioral relevance of oscillatory brain states. Some consider them to be a side effect of anatomical connectivity, with little or no role in guiding action. Others ...
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(Massachusetts Institute of Technology, 2016)Loss of function mutations in the X-linked gene encoding for MeCP2 are the underlying genetic cause for Rett Syndrome (RTT), a devastating neurodevelopmental disorder that primarily affects girls. While the function of ...
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(Massachusetts Institute of Technology, 2006)Despite decades of evidence for functional plasticity in the adult brain, the role of structural plasticity in its manifestation remains unclear. cpg15 is an activity-regulated gene encoding a membrane-bound ligand that ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2010)The basal ganglia, and specifically the sensorimotor (dorsolateral) striatum, have been implicated in stimulus-response learning. Here, I analyze the role the striatum plays in learning. We recorded from neurons of the ...
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(Massachusetts Institute of Technology, 2006)Regulation of gene transcription by neuronal activity is thought to be key to the translation of sensory experience into long-term changes in synaptic structure and function. Here we show that cgp15, a gene encoding an ...
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(Massachusetts Institute of Technology, 2016)The striatum is the largest nucleus in the basal ganglia and the recipient of dense dopamine input. Multiple cortico-basal ganglia-thalamic loops are thought to function together during the learning and performance of ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2016)Stressors are known to impact eating behaviors. However, recapitulating the intricate interplay between chronic stress and aberrant human eating patterns in an animal model remains a challenge. Notably, binge eating, a ...
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(Massachusetts Institute of Technology, 2011)This dissertation documents how healthy aging and Parkinson's disease (PD) affect brain anatomy and physiology and how these neural changes relate to measures of cognition and perception. While healthy aging and PD are ...
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(Massachusetts Institute of Technology, 2016)Why do languages have the words they do instead of some other set of words? In the first part of this thesis, I argue that cognitive and communicative demands strongly influence the structure of the lexicons of natural ...
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(Massachusetts Institute of Technology, 2004)(cont.) increased activity whenever recollection was attempted, independent of the level of recollection success. The results are consistent with the hypothesis that increased left-lateralized retrieval activity in older ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2015)The trained enhancement of working memory and visual attention has both theoretical implications for understanding the architectures of cognition, as well as practical implications for education and clinical treatment. In ...
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(Massachusetts Institute of Technology, 2005)(cont.) baseline, and that some coherence-based approaches best predict the human data. However, coherence-based algorithms that operate on trees did not perform as well as coherence-based algorithms that operate on more ...
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