Successful interaction with the external world requires choosing appropriate actions in the context of available choices. Such decisions require the evaluation of the reward magnitude, or value, associated with each potential ...

Long term potentiation (LTP) of synaptic transmission at the CA3-CA1 hippocampal synapse is a model synaptic plasticity mechanism that may underlie hippocampal dependent learning and memory. Inhibition of post-synaptic ...

The ability to group stimuli into meaningful categories is a fundamental cognitive process though little is known its neuronal basis. To address this issue, we trained monkeys to perform a categorization task in which they ...

Regulation of gene transcription by neuronal activity is thought to be key to the translation of sensory experience into long-term changes in synaptic structure and function. Here we show that cgp15, a gene encoding an ...

This dissertation documents how healthy aging and Parkinson's disease (PD) affect brain anatomy and physiology and how these neural changes relate to measures of cognition and perception. While healthy aging and PD are ...

There is broad agreement that the hippocampus is crucially involved in the formation of richly-detailed, long term memories of events in humans. A key aspect of such memories is the temporal order and spatial context of ...

The ability to switch between tasks reflects a fundamental part of our intelligence. A foundation of this ability lies in perceiving and processing information pertinent to the situation at hand. It is our capacity to ...