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Browsing Theses - Biology by Title
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(Massachusetts Institute of Technology, 2004)(cont.) sites for CIpA and SspB; this spatial arrangement of signals allows for efficient modulation of proteolysis of ssrA-tagged proteins. Finally, additional substrates whose degradation may be regulated by the adaptor ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2008)Small RNAs of -22 nt length play a variety of roles in the biology of animals by repressing the translation or stimulating the degradation of complementary messenger RNAs. Depending on the structure of their precursors, ...
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(Massachusetts Institute of Technology, 2008)The synthetic multivulva (synMuv) genes act redundantly to inhibit vulval fates in Caenorhabditis elegans. These genes are grouped into three classes called A, B and C. The class A genes encode putative transcription ...
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(Massachusetts Institute of Technology, 2012)Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...
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(Massachusetts Institute of Technology, 1930)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2010)A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively ...
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(Massachusetts Institute of Technology, 1994)
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease (Massachusetts Institute of Technology, 1999)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2010)Tumor development is a multi-step process driven by the collective action of gain-of-function mutations in oncogenes and loss-of-function alterations in tumor suppressor genes. The particular spectrum of mutations in a ...
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(Massachusetts Institute of Technology, 2008)PDZK1 is a four PDZ-domain containing cytoplasmic adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2000)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2006)While a fundamental feature of human melanoma is its tendency to metastasize to numerous organs throughout the body, very few animal models recapitulate this essential aspect of the disease. In the work described, it is ...
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