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Browsing Theses - Biology by Issue Date

Research and Teaching Output of the MIT Community

Browsing Theses - Biology by Issue Date

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  • Kravarik, Kellie M. (Kellie Marie) (Massachusetts Institute of Technology, 2018)
    Planarians are well known for their ability to regenerate an entire animal from small tissue fragments. Planarian regeneration requires a population of dividing cells called neoblasts that are distributed throughout the ...
  • Heer, Natalie C. (Natalie Claire) (Massachusetts Institute of Technology, 2018)
    Creating biological form requires the generation of forces to rearrange tissues, as well as the patterning and organizational control of those forces to create the correct shapes. Force generation by actomyosin networks ...
  • Falla Castillo, Diana Alejandra (Massachusetts Institute of Technology, 2018)
    Plasmodium falciparum is the causative agent of the most severe form of human malaria, a mosquito-borne disease that remains a major global health problem. The efforts to create new antimalarial drugs and effective vaccines ...
  • Besada, Rana Hany (Massachusetts Institute of Technology, 2018)
    B-cell acute lymphoblastic leukemia is the most common pediatric cancer, responsible for the most cancer-related deaths in children. Advances in chemotherapy over the past half-century have steadily increased the remission ...
  • Dubbury, Sara Jane (Massachusetts Institute of Technology, 2018)
    During transcription, cyclin-dependent kinases (CDKs) dynamically phosphorylate the C-terminal domain (CTD) of RNA Polymerase II (RNAPII) to recruit factors that coordinate transcription and mRNA biogenesis. Cdk12 ...
  • Davis, Kimberly Ryan (Massachusetts Institute of Technology, 2018)
    Surveillance of influenza A virus (IAV) is conducted for many different hosts including humans, swine, poultry, and wild birds. The surveillance samples are screened by various methods, but ultimately the isolates that are ...
  • Farzadfard, Fahim (Massachusetts Institute of Technology, 2018)
    Living cells are biological computers - constantly sensing, processing and responding to biological cues they receive over time and space. Devised by evolution, these biological machines are capable of performing many ...
  • Edenius, Maja Lena (Massachusetts Institute of Technology, 2018)
    Signaling pathways that respond to stress and sense nutrient availability are highly conserved throughout eukaryotes. In mammalian cells, these pathways have evolved to regulate immune responses, representing important ...
  • Bartlebaugh, Jordan Michael Elizabeth (Massachusetts Institute of Technology, 2018)
    Developmental and lineage plasticity have been observed in numerous malignancies, and have been correlated with tumor progression and drug resistance. However, little is known about the molecular mechanisms that enable ...
  • Thai, Kevin K. (Kevin Kinh) (Massachusetts Institute of Technology, 2018)
    Cancer is a disease of normal healthy cells that have accumulated genetic aberrations that contribute to uncontrolled cell divisions. Generally, cancer cells have acquired gain of function mutations in oncogenes that ...
  • Burton, Nicholas O. (Nicholas Oscar) (Massachusetts Institute of Technology, 2017)
    From the 4th century BC until the late 19th century AD philosophers and biologists ranging from Hippocrates to Charles Darwin hypothesized that information about the environment could be passed from parents to progeny. ...
  • Brownlee, Emily Fay (Massachusetts Institute of Technology, 2017)
    Protists play important roles in grazing and nutrient recycling, but quantifying these roles has been hindered by difficulties in collecting, culturing, and observing these often-delicate cells. During long-term deployments ...
  • Wang, Xinchen, Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2017)
    Genetic mapping of the drivers of complex human phenotypes and disease through the genome-wide association study (GWAS) has identified thousands of causal genetic loci in the human population. However, genetic mapping ...
  • Stanciu, Monica, Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2017)
    Glioblastoma (GBM), the most prevalent primary brain tumor in adults, remains a largely intractable malignancy that carries an extremely poor prognosis. Large scale genomic analyses have greatly expanded our knowledge of ...
  • Ellis, Donald Christian (Massachusetts Institute of Technology, 2017)
    An unmet and paramount need in the field of cancer research is to rapidly translate basic biological findings to clinically relevant therapeutics for cancer patients. Recent technological advances have generated many ...
  • Coravos, Jonathan S. (Jonathan Stuck) (Massachusetts Institute of Technology, 2017)
    Actin and myosin generate contractile forces to change tissue and cell shape. These shape changes are essential for many biological functions, ranging from muscle contraction to tissue morphogenesis in development. While ...
  • Cruz Ruiz, Victor E. (Victor Emmanuel Cruz Ruiz) (Massachusetts Institute of Technology, 2017)
    The nuclear envelope (NE) is comprised of a double membrane bilayer that physically separates the nucleoplasm from the cytoplasm. Information can be transmitted through the NE by molecular exchange through the nuclear pore ...
  • Peterson, Alexis W (Massachusetts Institute of Technology, 2017)
    Here, I describe the process of generating single-domain antibodies which bind to splice variants of fibronectin containing EIIIA or EIIIB. Alpacas were immunized with either purified antigen cocktails, or from the ECM of ...
  • Van der Hoop, Julie M (Massachusetts Institute of Technology, 2017)
    Animal movement is motivated in part by energetic constraints, where fitness is maximized by minimizing energy consumption. The energetic cost of movement depends on the resistive forces acting on an animal; changes in ...
  • Bors, Eleanor Kathleen (Massachusetts Institute of Technology, 2017)
    Every genome tells a story. This dissertation contains four such stories, focused on shared themes of marine population dynamics and rapid change, with an emphasis on invasive marine species. Biological invasions are often ...
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