Regulated intracellular protein degradation is critical for cellular viability. In many organisms, degradation controls cell-cycle progression, executes responses to stress-inducing environmental changes, and enables the ...

Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The ...