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Browsing Theses - Biology by Title
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(Massachusetts Institute of Technology, 2013)
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(Massachusetts Institute of Technology, 2010)Regulated intracellular protein degradation is critical for cellular viability. In many organisms, degradation controls cell-cycle progression, executes responses to stress-inducing environmental changes, and enables the ...
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(Massachusetts Institute of Technology, 2016)Huntington's disease is one of nine expanded (CAG) repeat disorders. The expansion in Huntington's disease lies in the first exon of the huntingtin (HTT) gene and is pathogenic when (CAG)>/= 40 . Individuals with Huntington's ...
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(Massachusetts Institute of Technology, 2017)mTORC1 is a master regulator of cell growth that responds to diverse environmental inputs and is deregulated in human diseases, such as cancer and epilepsy. One important input to this system is amino acids, such as leucine, ...
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(Massachusetts Institute of Technology, 1999)The rat Lymphopenia gene, Lyp, is absolutely required for the development of Insulin-Dependent Diabetes Mellitus (IDDM) in the BioBreeding (BB) rat. In order to overcome the lack of positional cloning resources available ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2008)The bgaH gene isolated from Haloferax lucentensis codes for P-galactosidase. To study the function of initiator tRNAs in translation initiation in Haloferax volcanii, the initiator AUG codon of the bgaH gene was mutated ...
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(Massachusetts Institute of Technology, 2013)The high density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), is a cell surface glycoprotein that controls HDL structure and metabolism by mediating cellular selective uptake of lipids from HDL. ...
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(Massachusetts Institute of Technology, 2011)Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2015)Cancer is a disease defined by the uncontrolled proliferation of cells. Using primarily in vitro approaches, researchers have gained critical insight into how different oncogenic mutations alter the regulation of metabolic ...
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(Massachusetts Institute of Technology, 1955)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2012)Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The ...
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(Massachusetts Institute of Technology, 1995)
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