Regulated intracellular protein degradation is critical for cellular viability. In many organisms, degradation controls cell-cycle progression, executes responses to stress-inducing environmental changes, and enables the ...

The rat Lymphopenia gene, Lyp, is absolutely required for the development of Insulin-Dependent Diabetes Mellitus (IDDM) in the BioBreeding (BB) rat. In order to overcome the lack of positional cloning resources available ...

The bgaH gene isolated from Haloferax lucentensis codes for P-galactosidase. To study the function of initiator tRNAs in translation initiation in Haloferax volcanii, the initiator AUG codon of the bgaH gene was mutated ...

Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

Cancer is a disease defined by the uncontrolled proliferation of cells. Using primarily in vitro approaches, researchers have gained critical insight into how different oncogenic mutations alter the regulation of metabolic ...