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Now showing items 739-750 of 750

Ultraviolet radiation-induced aggregation of human lens protein [g̳a̳m̳m̳a̳]D-crystallin : characterization of the protective tryptophan clusters and key sensitizing residues

Schafheimer, Nathaniel (Steven Nathaniel) (Massachusetts Institute of Technology, 2013)
Understanding and harnessing energy-dependent proteolysis for controlled protein degradation in bacteria

Davis, Joseph H. (Joseph Harry), III (Massachusetts Institute of Technology, 2010)

Regulated intracellular protein degradation is critical for cellular viability. In many organisms, degradation controls cell-cycle progression, executes responses to stress-inducing environmental changes, and enables the ...
Use of a conservation-of-linkage strategy to identify a candidate for the rat Lymphopenia gene

MacMurray, Armand J. (Armand John), 1963- (Massachusetts Institute of Technology, 1999)

The rat Lymphopenia gene, Lyp, is absolutely required for the development of Insulin-Dependent Diabetes Mellitus (IDDM) in the BioBreeding (BB) rat. In order to overcome the lack of positional cloning resources available ...
Use of a pseudotyped retoviral vector to accomplish insertional mutagenesis in zebrafish

Amsterdam, Adam (Adam Henry), 1967- (Massachusetts Institute of Technology, 1998)
Use of bgaH as a reporter gene for studying translation initiation in the archaeon Haloferax volcanii

Sullivan, Eric L., S.M. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2008)

The bgaH gene isolated from Haloferax lucentensis codes for P-galactosidase. To study the function of initiator tRNAs in translation initiation in Haloferax volcanii, the initiator AUG codon of the bgaH gene was mutated ...
Using chemical biology as a tool to probe the mechanism of the HDL receptor

Yu, Miao, Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2013)

The high density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), is a cell surface glycoprotein that controls HDL structure and metabolism by mediating cellular selective uptake of lipids from HDL. ...
Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

Treusch, Sebastian (Massachusetts Institute of Technology, 2011)

Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...
UTH1 and the genetic control of aging in the yeast, Saccharomyces

Austriaco, Nicanor Robles, 1968- (Massachusetts Institute of Technology, 1996)
X-ray diffraction analysis of the structure of deoxyribonucleic acid

Wyckoff, Harold W (Massachusetts Institute of Technology, 1955)
Yeast and mammalian RNA polymerase II holoenzymes

Chao, David M. (David Min) (Massachusetts Institute of Technology, 1997)
ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition

Kah, Kong Jie (Massachusetts Institute of Technology, 2012)

Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The ...
β-sheet interactions with DNA revealed by the arc repressor-operator complex

Raumann, Brigitte Elke (Massachusetts Institute of Technology, 1995)

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