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Browsing Biology - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2010)In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been ...
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(Massachusetts Institute of Technology, 2013)Seafloor digital imagery and bathymetric data are used to evaluate the volcanic characteristics of the 85°E segment of the ultraslow spreading Gakkel Ridge (9 mm yr-¹). Imagery reveals that ridges and volcanic cones in the ...
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DegP related proteases in Escherichia coli and carboxyl-terminal tagging of proteins for degradation (Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2003)Membrane glycoproteins of the secretory pathway that cannot adopt their native conformation are targeted for dislocation from the endoplasmic reticulum (ER) membrane for subsequent degradation by the cytosolic proteasome. ...
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(Massachusetts Institute of Technology, 2010)The refolding and elimination of damaged and aggregated proteins requires the concerted effort of several branches of the protein quality-control network. This network includes refolding chaperones, disaggregases, holdases ...
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(Massachusetts Institute of Technology, 2012)Computational design of protein-protein interaction specificity is a powerful tool to examine and expand our understanding about how protein sequence determines interaction specificity. It also has many applications in ...
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(Massachusetts Institute of Technology, 2009)Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes: for example, some cells lyse while others survive as lysogens. A quantitative molecular model of lambda infection supports the ...
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Determining protein interaction specificity of native and designed bZIP family transcription factors (Massachusetts Institute of Technology, 2012)Protein-protein interactions are important for almost all cellular functions. Knowing which proteins interact with one another is important for understanding protein function as well as for being able to disrupt their ...
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(Massachusetts Institute of Technology, 2006)In mitotic cell cycles, the genome must be replicated fully in each cell cycle to ensure the normal complement of chromosomes. Failure to replicate chromosomes fully or a failure to limit replication to once-per-cell-cycle ...
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(Massachusetts Institute of Technology, 2007)Developmental gene amplification in the ovarian follicle cells of Drosophila provides a powerful system for the study of metazoan DNA replication. Amplification produces 100kb gradients of amplified DNA through repeated ...
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(Massachusetts Institute of Technology, 2008)Meiosis is a modified cell cycle in which two round of chromosome segregation occur without an intervening DNA synthesis phase. As in mitosis, these cell divisions are driven in part by proteolysis mediated by the ...
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(Massachusetts Institute of Technology, 2006)Mammalian germ cells arise during early embryogenesis and migrate to the developing gonad where, under the direction of the somatic environment, they initiate distinct sex-specific developmental programs resulting in the ...
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(Massachusetts Institute of Technology, 1992)
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(Massachusetts Institute of Technology, 1977)
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(Massachusetts Institute of Technology, 2008)This thesis describes the development and application of a new tool for profiling marine microbial communities. Chapter 1 places the tool in the context of the range of methods used currently. Chapter 2 describes the ...
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(Massachusetts Institute of Technology, 2008)RNA interference (RNAi) manages many aspects of eukaryotic gene expression through sequence-specific interactions with RNA. Short RNAs, 20-30 nucleotides in length, guide the various effector proteins of RNAi to silence ...
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(Massachusetts Institute of Technology, 2007)Induction of angiogenesis is a critical and rate-limiting step in the progression of cancer. It is widely acknowledged that this induction requires the concomitant stimulation of pro-angiogenic and repression of anti-angiogenic ...
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(Massachusetts Institute of Technology, 1976)
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(Massachusetts Institute of Technology, 2013)RNA interference (RNAi) is a eukaryotic pathway for the post-transcriptional regulation of gene expression. In the simplest form of RNAi, a double-stranded RNA (dsRNA) trigger is converted into small-RNA duplexes by the ...
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