Microbes occupy a wide range of important niches ranging from global biogeochemical cycles to metabolism in the human gut. Yet microbes rarely act in isolation. Instead, they thrive in complex communities with myriad ...

Marine thecate heterotrophic dinoflagellates likely play an important role in the consumption of primary productivity and in the trophic structure of the plankton, yet we know little about these species. This thesis expanded ...

Activating mutations in RAS oncogenes commonly arise in human cancers. However, in experimental settings, oncogenic RAS has most often been studied at supraphysiological levels of expression. Importantly, work by others ...

Caspases play an important role in apoptosis, or programmed cell death. In particular, three highly related effector caspases, caspases-3, -6, and -7, translate upstream death signals into the physical manifestations of ...

Nanobiotechnology aims to exploit biomolecular recognition and self-assembly capabilities for integrating advanced materials into medicine and electronics. In particular, peptides have exhibited the ability to specifically ...

The human body is made up of a diverse array of cell types, each with specialized properties and functions that support the organism as a whole. Despite this variability, with few exceptions, these cells contain the same ...

(cont.) The vertebrate-specific miR-196 family is encoded at three paralogous loci in the mammalian Hox clusters, and has complementarity to messages of several Hox genes, including Hox8 paralogues. RNA fragments diagnostic ...

Understanding how phenotypes evolve through natural selection is a fundamental question of biology. Microbial evolution studies provide the rare opportunity to experimentally elucidate the changes that allow an organism ...