Browsing Biology - Ph.D. / Sc.D. by Title
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Browsing Biology - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1983)
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(Massachusetts Institute of Technology, 2002)This thesis describes the identification and characterization of a novel gene, GRP50 (Golgi-associated ankyrin repeat protein of 50 kilodaltons), which encodes a highly conserved mammalian protein exhibiting a unique ...
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(Massachusetts Institute of Technology, 2010)Chemotherapeutic drug resistance is a major cause of cancer treatment failure. While much attention has been focused on the genetics of tumor development, less is known about the genetic determinants of therapeutic outcome. ...
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Identification and characterization of novel Rhizobium meliloti genes involved in carbon metabolism (Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2009)Nearly 90% of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute ...
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(Massachusetts Institute of Technology, 2006)Huntington's disease (HD) is a progressive degenerative neurological disorder. Individuals who inherit the IT15 gene with an expansion of the CAG repeat region inevitably succumb to increasingly sever motor, psychological, ...
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(Massachusetts Institute of Technology, 2006)The class A, B, and C synthetic Multivulva (synMuv) genes act redundantly to antagonize Ras-mediated vulval induction in C. elegans. Many of these genes encode proteins that are likely to function in transcriptional ...
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(Massachusetts Institute of Technology, 2008)Our lab identified the tandem BRCT domains of PTIP function as a DNA damage responsive phospho binding domain that recognizes proteins phosphorylated by ATM and ATR after DNA damage. The PTIP tandem BRCT domains are ...
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(Massachusetts Institute of Technology, 2008)Aging of an organism is determined by both stochastic and genetic components. The importance of genes is illustrated by the discovery of single gene mutations that alter lifespans of species ranging from invertebrates C. ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2006)The division of a eukaryotic cell into two daughter cells is controlled by cyclin dependent kinase (CDK). Entry into mitosis is promoted by the activity of CDK complexed with mitotic cyclins. Upon faithful segregation of ...
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(Massachusetts Institute of Technology, 2011)The mTOR protein kinase nucleates two complexes, mTORC1 and mTORC2. Collectively, the two complexes regulate processes important for cell growth and proliferation, including protein synthesis, autophagy, metabolism, and ...
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(Massachusetts Institute of Technology, 2011)The eukaryotic cell cycle refers to a sequence of events by which a cell duplicates its genomic DNA and divides into two daughter cells. Deregulation of the cell cycle can cause aberrant cell proliferation, as well as ...
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(Massachusetts Institute of Technology, 1989)
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(Massachusetts Institute of Technology, 2004)Postsynaptic density protein-95 (PSD-95) is the second most abundantly expressed synaptic protein in the postnatal forebrain. It is an integral part of the postsynaptic scaffolding complex and helps recruit receptors, ...
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(Massachusetts Institute of Technology, 2012)Regulation of gene expression in eukaryotes is highly precise and complex. Changes in expression can define the fate of each cell, convert healthy tissues to diseased ones, and even lead to speciation. Regulation occurs ...
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(Massachusetts Institute of Technology, 2011)The process by which the totipotent zygote undergoes development into an adult organism using a single genome is the foundation for epigenetics and cellular differentiation. Somatic cell nuclear transfer experiments (SCNT) ...
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