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Browsing Biology - Ph.D. / Sc.D. by Issue Date

Research and Teaching Output of the MIT Community

Browsing Biology - Ph.D. / Sc.D. by Issue Date

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  • Stinson, Benjamin M. (Benjamin Michael) (Massachusetts Institute of Technology, 2015)
    ATP-powered proteases enforce protein quality-control and regulation in all domains of life. ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power conformational changes that unfold and ...
  • Todorova, Tanya (Tanya Todorova) (Massachusetts Institute of Technology, 2015)
    Poly(ADP-ribose) polymerase-13 (PARP13) is a member of the PARP family of proteins - enzymes that use NAD+ to synthesize a posttranslational protein modification called poly(ADP-ribose) (PAR). PARPs function in multiple ...
  • Almada, Amalia Aruda (Massachusetts Institute of Technology, 2015)
    Zooplankton, such as copepods, are highly abundant environmental reservoirs of many bacterial pathogens. Although copepods are known to support diverse and productive bacterial communities, little is understood about whether ...
  • Kim, Eunha, Ph. D (Massachusetts Institute of Technology, 2015)
    Islet transplantation has significant potential for the treatment of type I diabetes, but an immunoprotective barrier is necessary to protect the donor tissue from host rejection and to eliminate the need for systemic ...
  • Zinshteyn, Boris (Massachusetts Institute of Technology, 2015)
    The goal of this thesis is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages ...
  • Herrera Monroy, Santiago (Massachusetts Institute of Technology, 2015)
    Hydrothermal vents and coral ecosystems are conspicuous biological hot spots in the deep-sea. These ecosystems face increasing threats from human activities. Having thorough taxonomic inventories as well as understanding ...
  • Alvarez, Juan (Juan Rene Alvarez Dominguez) (Massachusetts Institute of Technology, 2015)
    Mammalian genomes comprise thousands of non-protein-coding genes. These can produce small non-coding RNAs (such as rRNAs and tRNAs), as well as long non-coding RNAs (lncRNAs), which are >200nt and resemble mRNAs in their ...
  • Damon, Jadyn Rose (Massachusetts Institute of Technology, 2015)
    Ubiquitin and ubiquitin-like proteins (UBLs) have a diverse array of functions that serve to regulate many cellular processes in eukaryotic cells. The ubiquitin-related modifier UrmI is a conserved UBL that, in addition ...
  • Hunter-Cevera, Kristen Rachell (Massachusetts Institute of Technology, 2014)
    Synechococcus is a ubiquitous marine primary producer. Our understanding of the factors that determine its abundance has been limited by available observational tools, which have not been able to resolve population dynamics ...
  • Lee, Clarissa Ci (Massachusetts Institute of Technology, 2014)
    Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...
  • Merkin, Jason Jay (Massachusetts Institute of Technology, 2014)
    In this thesis, I describe investigations into the evolution of splicing in mammals. I first investigate a small class of alternative splicing events, tandem splice sites, and show how they are used to introduce and remove ...
  • McFaline-Figueroa, José L (Massachusetts Institute of Technology, 2014)
    Glioblastoma (GBM) is the most common and malignant form of brain cancer. After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. ...
  • Piccioli, Zachary D. (Zachary David) (Massachusetts Institute of Technology, 2014)
    The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we ...
  • Oromendia, Ana Belen (Massachusetts Institute of Technology, 2014)
    Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is only beginning to be understood. ...
  • Israelsen, William James (Massachusetts Institute of Technology, 2014)
    Cancer is a disease of inappropriate cell proliferation, and central carbon metabolism is highly regulated to support the unique anabolic needs of proliferating cells. Pyruvate kinase, the enzyme catalyzing the final step ...
  • Bosson, Andrew D. (Andrew David) (Massachusetts Institute of Technology, 2014)
    regulators of gene expression in a wide range of organisms and biological processes. Each miRNA guides Argonaute (Ago) protein complexes to target and repress hundreds of genes in a sequence-dependent manner. To identify ...
  • Thornton, Seraphim R (Massachusetts Institute of Technology, 2014)
    During mammalian development, a single founding cell must produce all of the different types of cells in the adult organism. What are the regulatory mechanisms required to coordinate the necessary gene expression networks ...
  • Faddah, Dina Adel (Massachusetts Institute of Technology, 2014)
    Three years before the start of this thesis, Yamanaka and Takahashi published a groundbreaking paper entitled "Induced of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." A ...
  • Sosa-Alvarado, Brian A. (Brian Alexander) (Massachusetts Institute of Technology, 2014)
    The nucleus is the hallmark of the eukaryotic cell. It contains most of the genetic material and it separates the processes of replication and transcription from that of translation. Communication between the nucleus and ...
  • Vyas, Sejal (Sejal Kamlesh) (Massachusetts Institute of Technology, 2014)
    The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs ...
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