Browsing Theses - Chemical Engineering by Title
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Browsing Theses - Chemical Engineering by Title
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 2006)We have developed the first protease specificity engineering technology intended to serve as a general-purpose source of target-specific protease mutants with potential therapeutic applications. We used this E. coli-based ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1984)
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(Massachusetts Institute of Technology, 2006)T cells are activated by recognition of foreign peptides displayed on the surface of antigen presenting cells (APCs), an event that triggers assembly of a complex microscale structure at the T cell-APC interface known as ...
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(Massachusetts Institute of Technology, 1977)
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(Massachusetts Institute of Technology, 2009)There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...
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(Massachusetts Institute of Technology, 2004)This thesis investigates potential improvements to the manufacturing process through the implementation of process analytical technologies (PAT) in the heavily regulated pharmaceutical industry. The thesis focuses on the ...
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(Massachusetts Institute of Technology, 2008)Due to the highly regulated environment, it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. ...
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(Massachusetts Institute of Technology, 2009)The operating cost of a membrane filtration system is generally determined by two major factors: the permeability of the membrane to water, and the lifetime of the membrane. Both of these are strongly affected by the ...
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(Massachusetts Institute of Technology, 2007)Pretargeted radioimmunotherapy (PRIT) of cancer improves upon conventional radioimmunotherapy (RIT) by decoupling the pharmacokinetics of the targeting agent and the radioisotope. In order to improve upon PRIT, we have ...
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(Massachusetts Institute of Technology, 2008)The extracellular matrix (ECM) has been shown to be a significant source of hindrance to the transport of macromolecules in solid tumors. This thesis shows that by limiting their interstitial transport, the tumor ECM can ...
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(Massachusetts Institute of Technology, 2010)Steady state process simulation is used throughout the chemical industry to guide development and help reduce uncertainty and risk. Volumetric equations of state (EOS)s are the most robust of the numerous methods available ...
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(Massachusetts Institute of Technology, 2007)Hepatic stem cells in adult rats are activated by chemical injury to the liver, causing hepatic progenitor cells to proliferate, integrate into the hepatic plates, and differentiate into hepatocytes. In an attempt to model ...
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(Massachusetts Institute of Technology, 2010)Approximately 60-70% of all recombinant human glycoproteins are produced in Chinese Hamster Ovary (CHO) cells. Production in CHO cells, however, is often plagued by low productivity when compared with other host cell lines, ...
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(Massachusetts Institute of Technology, 2000)Technologies for dynamic simulation of chemical process flowsheets, as implemented in equation-based dynamic simulators,allow solution of fairly sophisticated process models, that include detailed descriptions of physical ...
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(Massachusetts Institute of Technology, 1989)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2007)The lipid bilayer forms the basic structure of the cell membrane, which is a heterogeneous matrix of proteins and lipids that provides a barrier between the interior of a cell and its outside environment. Protein and lipid ...
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