Browsing Chemistry - Ph.D. / Sc.D. by Title
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Browsing Chemistry - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2005)Within cellular signaling, protein phosphorylation is the post-translational modification most frequently used to regulate protein activity. Protein kinases and phosphoprotein phosphatases generate and terminate these ...
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(Massachusetts Institute of Technology, 2007)Protein phosphorylation is a central regulatory mechanism in signal transduction pathways and cellular migration. Current genetic strategies for the study of phosphorylation, including gene knockout and point mutation, are ...
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(Massachusetts Institute of Technology, 2004)The intermolecular, three-component carbonyl ylide cycloaddition of a diazo compound, aldehyde, and carbon-carbon multiple bond is a powerful method to construct five-membered oxygen heterocycles. An adjacent dicobalt ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 1999)
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(Massachusetts Institute of Technology, 2007)This thesis presents a study of the reaction between an (NHC)gold(I) fluoride complex (NHC = N-heterocyclic carbene) and alkynes (Chapter 1). Gold(I) and fluoride add trans across the triple bond of 3-hexyne and ...
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(Massachusetts Institute of Technology, 2004)In Part I the development of a new method for the construction of oxindoles and benzofuranones bearing quaternary stereocenters is discussed. A planar-chiral PPY derivative catalyzes the O-to-C acyl group migration (Black ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2005)The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2006)Purine biosynthesis has been used as a paradigm for the study of metabolism of unstable molecules. Both phosphoribosylamine (PRA) and N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) have estimated half-lives in vivo of ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2002)T cells are activated by the engagement of their surface T cell receptors (TCR) by antigenic peptide bound to major histocompatibility complex (MHC). The success or failure of this TCR to MHC-peptide interaction determines ...
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(Massachusetts Institute of Technology, 2008)Density functional theory (DFT) is a computationally efficient formalism for studying electronic structure and dynamics. In this work, we develop DFT-based excited-state methods to study electron transport, Rydberg excited ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2004)The chemistry of fluorine, F2, and xenon difluoride, XeF2, with clean Si are nearly indistinguishable. Both species react via the atom abstraction mechanism, whereby a surface dangling bond abstracts a F atom from the ...
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(Massachusetts Institute of Technology, 1968)
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