Browsing Harvard-MIT Program of Health Sciences and Technology by Title
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Browsing Harvard-MIT Program of Health Sciences and Technology by Title
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(Massachusetts Institute of Technology, 2010)Metastasis, the migration of cancer cells from the primary site of tumorigenesis and the subsequent invasion of secondary tissues, causes the vast majority of cancer deaths. To spread, metastatic cells dramatically rearrange ...
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(Massachusetts Institute of Technology, 2014)This work investigates the fundamental processes used by mammalian cells and organisms to make decisions during embryonic development. Current technologies that evaluate biological phenomenon often force a compromise between ...
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(Massachusetts Institute of Technology, 2008)This thesis describes results from two projects related to the efferent innervation of the cochlea. First, we investigated peripheral olivocochlear effects of sustained contralateral broadband noise in anesthetized guinea ...
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(Massachusetts Institute of Technology, 2011)This thesis explores two aspects of small regulatory RNAs in mammals: (1) the genomic origin of mammalian piwi-interacting RNAs (piRNAs), (2) the evolutionary and functional implication of the seed-based target recognition ...
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(Massachusetts Institute of Technology, 2013)One in every 88 children is diagnosed with Autism Spectrum Disorders (ASDs), a set of neurodevelopmental conditions characterized by social impairments, communication deficits, and repetitive behavior. ASDs have a substantial ...
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(Massachusetts Institute of Technology, 2012)Voltage-gated sodium (Nav) channels are diverse, comprising nine known mammalian subunits, which are classified pharmacologically into tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-insensitive (TTX-1) categories. The ...
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(Massachusetts Institute of Technology, 2003)Hair cells are the exquisitely-sensitive mechanosensory transducers of the inner ear. While the electrophysiology of hair cells has been extensively studied, little is known about the vital background processes that maintain ...
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(Massachusetts Institute of Technology, 2014)Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...
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(Massachusetts Institute of Technology, 2006)Bilateral cochlear implantation is becoming more common as clinicians attempt to provide better sound-source localization and speech reception in noise for cochlear implant (CI) users. While some improvement over the ...
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Sound temporal envelope and time-patterns of activity in the human auditory pathway : an fMRI study (Massachusetts Institute of Technology, 2002)The temporal envelope of sound strongly influences the intelligibility of speech, pattern analysis, and the grouping of sequential stimuli. This thesis examined the coding of sound temporal envelope in the time-patterns ...
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(Massachusetts Institute of Technology, 1990)
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(Massachusetts Institute of Technology, 2004)(cont.) parametric effect, which can be considered an imaging artifact. Additionally, it may be possible to use the nonlinear interaction of scattered waves to form images that rely on the presence of small scatterers; a ...
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(Massachusetts Institute of Technology, 2012)Space radiation poses a significant hazard to astronauts on long-duration missions, and the low fluences of charged particles characteristic of this field suggest that bystander effects, the phenomenon in which a greater ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2002)Osteoarthritis is a painful degenerative joint disease affecting millions of people in the U.S. The pathogenesis of articular cartilage disease is characterized by softening of cartilage and loss and disruption of constituent ...
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(Massachusetts Institute of Technology, 2000)
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(Massachusetts Institute of Technology, 2004)This thesis integrates hardware development, data analysis, and mathematical modeling to facilitate our understanding of brain cognition. Exploration of these brain mechanisms requires both structural and functional knowledge ...
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(Massachusetts Institute of Technology, 2005)Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...
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(Massachusetts Institute of Technology, 1994)
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