Browsing Harvard-MIT Program of Health Sciences and Technology by Title
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Browsing Harvard-MIT Program of Health Sciences and Technology by Title
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(Massachusetts Institute of Technology, 2010)This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...
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(Massachusetts Institute of Technology, 2009)Synaptic ribbons are electron-dense structures surrounded by vesicles and anchored to the presynaptic membrane of photoreceptors, retinal bipolar cells and hair cells. Ribbon synapses are characterized by sustained exocytosis ...
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(Massachusetts Institute of Technology, 2008)Electronic prescription software is replacing traditional handwritten medication orders. This development however doesn't come without a cost and speed has been one of the most complained about issues. It is important to ...
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(Massachusetts Institute of Technology, 2009)Amyloids and prion proteins are clinically and biologically important beta-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means. In addition, significant ...
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(Massachusetts Institute of Technology, 2007)Complex traits are conditions that, as a result of the complex interplay among genetic and environmental factors, have wide variability in progression and manifestation. Because most common diseases with high morbidity and ...
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(Massachusetts Institute of Technology, 2012)Over the past ten years there has been increasing public concern regarding the rising costs of pharmaceuticals. Drug expenditure is the fastest growing sector of healthcare costs in the United States. The structure of the ...
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(Massachusetts Institute of Technology, 2013)Acoustic overexposure can cause death of cochlear nerve fibers, even if elevations in cochlear sensitivity are reversible and even if there is no hair cell loss. We hypothesized that this primary neural degeneration does ...
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(Massachusetts Institute of Technology, 2004)(cont.) Our methods analyze the coupling between instantaneous lung volume and heart rate and, subsequently, derive representative indices of parasympathetic and sympathetic control based on physiological and experimental ...
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(Massachusetts Institute of Technology, 2008)Electronic transmission of protected health information has become pervasive in research, clinical, and public health investigations, posing substantial risk to patient privacy. From clinical genetic screenings to publication ...
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(Massachusetts Institute of Technology, 2003)A recent analysis by the Tufts Center for the Study of Drug Development estimates that the cost of developing a single new chemical entity (NCE) into a successful therapeutic agent is $802 million. This figure is largely ...
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(Massachusetts Institute of Technology, 1999)
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(Massachusetts Institute of Technology, 2007)Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, ...
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(Massachusetts Institute of Technology, 2008)Genetic mapping by association is an unbiased approach to discover genes and pathways influencing disease traits and response to drugs and environmental exposures. There are two key obstacles to mapping in humans: (1) The ...
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(Massachusetts Institute of Technology, 1988)
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(Massachusetts Institute of Technology, 2008)It is now widely accepted that cells are capable of processing both mechanical and chemical signals from the extracellular environment. Exactly how these two factors affect the cell biology in the context of physiological ...
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(Massachusetts Institute of Technology, 2011)Understanding the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of ...
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(Massachusetts Institute of Technology, 2009)Embryonic Stem Cells (ESCs) are pluripotent and thus are considered the "cell type of choice". ESCs exhibit several phenotypic traits (e.g., proliferation, differentiation, apoptosis, necrosis, etc.) and when differentiated ...
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(Massachusetts Institute of Technology, 2005)Alternative pre-messenger RNA splicing is a crucial step in eukaryotic gene expression, and therefore it is subject to tight regulation. Given its importance in conferring protein diversity, alternative splicing is sensitive ...
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(Massachusetts Institute of Technology, 2009)The current clinical standard for cervical cancer diagnosis is colposcopy, a procedure that involves visual inspection and biopsy of at-risk tissue, followed by histopathology. The major objective of colposcopy is detection ...
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(Massachusetts Institute of Technology, 2012)The field of medical image analysis continues to expand as magnetic resonance imaging (MRI) technology advances through increases in field strength and the development of new image acquisition and reconstruction methods. ...
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