Browsing Harvard-MIT Program of Health Sciences and Technology by Title
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Browsing Harvard-MIT Program of Health Sciences and Technology by Title
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(Massachusetts Institute of Technology, 2008)Electronic transmission of protected health information has become pervasive in research, clinical, and public health investigations, posing substantial risk to patient privacy. From clinical genetic screenings to publication ...
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(Massachusetts Institute of Technology, 2003)A recent analysis by the Tufts Center for the Study of Drug Development estimates that the cost of developing a single new chemical entity (NCE) into a successful therapeutic agent is $802 million. This figure is largely ...
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(Massachusetts Institute of Technology, 1999)
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(Massachusetts Institute of Technology, 2007)Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, ...
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(Massachusetts Institute of Technology, 2008)Genetic mapping by association is an unbiased approach to discover genes and pathways influencing disease traits and response to drugs and environmental exposures. There are two key obstacles to mapping in humans: (1) The ...
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(Massachusetts Institute of Technology, 1988)
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(Massachusetts Institute of Technology, 2008)It is now widely accepted that cells are capable of processing both mechanical and chemical signals from the extracellular environment. Exactly how these two factors affect the cell biology in the context of physiological ...
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(Massachusetts Institute of Technology, 2011)Understanding the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of ...
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(Massachusetts Institute of Technology, 2009)Embryonic Stem Cells (ESCs) are pluripotent and thus are considered the "cell type of choice". ESCs exhibit several phenotypic traits (e.g., proliferation, differentiation, apoptosis, necrosis, etc.) and when differentiated ...
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(Massachusetts Institute of Technology, 2005)Alternative pre-messenger RNA splicing is a crucial step in eukaryotic gene expression, and therefore it is subject to tight regulation. Given its importance in conferring protein diversity, alternative splicing is sensitive ...
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(Massachusetts Institute of Technology, 2009)The current clinical standard for cervical cancer diagnosis is colposcopy, a procedure that involves visual inspection and biopsy of at-risk tissue, followed by histopathology. The major objective of colposcopy is detection ...
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(Massachusetts Institute of Technology, 2012)The field of medical image analysis continues to expand as magnetic resonance imaging (MRI) technology advances through increases in field strength and the development of new image acquisition and reconstruction methods. ...
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(Massachusetts Institute of Technology, 1984)
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 2006)This work is an attempt to explain wide variations in drug licensing deal value by using regression modeling to describe and predict the relationship between oncology drug deal characteristics and their licensing deal ...
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(Massachusetts Institute of Technology, 1984)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2011)This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...
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(Massachusetts Institute of Technology, 2004)The importance of the cochlear active mechanism in the reception of speech in different types of noise was explored. The perceptual effects of loudness recruitment, a consequence of loss of the active mechanism, were ...
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(Massachusetts Institute of Technology, 2000)Detecting the metabolic state of atherosclerotic lesions is a promise of nuclear medicine imaging. Several researchers are developing radiopharmaceuticals for atherosclerosis imaging. In this thesis, we provided procedural ...
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