Browsing Theses - Health Sciences and Technology by Issue Date
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Browsing Theses - Health Sciences and Technology by Issue Date
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(Massachusetts Institute of Technology, 2012)Efforts to sequence cancer genomes have begun to uncover comprehensive lists of genes altered in cancer. Unfortunately, the number and complexity of identified alterations has made dissecting the underlying biology of ...
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(Massachusetts Institute of Technology, 2012)The efficient isolation of specific bioparticles in lab-on-a-chip platforms is important for many applications in clinical diagnostics and biomedical research. The majority of microfluidic devices designed for specific ...
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(Massachusetts Institute of Technology, 2012)Space radiation poses a significant hazard to astronauts on long-duration missions, and the low fluences of charged particles characteristic of this field suggest that bystander effects, the phenomenon in which a greater ...
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(Massachusetts Institute of Technology, 2012)Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...
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(Massachusetts Institute of Technology, 2012)Afflicting almost 200 million worldwide, hepatitis C virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the ...
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(Massachusetts Institute of Technology, 2012)Ambulation is a very important part of everyday life and its absence has a detrimental effect on an individual's quality of life. While much is understood about the neurobiological systems involved in locomotion through ...
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(Massachusetts Institute of Technology, 2012)The incidence of autism spectrum disorders (ASD) has risen alarmingly in the United States, and is now thought to affect approximately 1 in 110 live births. Early diagnosis and intervention is the only treatment proven ...
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(Massachusetts Institute of Technology, 2012)Myotonic dystrophy (DM) is the most common form of adult onset muscular dystrophy, affecting more than 1 in 8000 individuals globally. The symptoms of DM are multi-systemic and include myotonia, severe muscle wasting, ...
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(Massachusetts Institute of Technology, 2012)Humans live in association with trillions of microbes and yet we know remarkably little about their symbiotic relationship. The role these microorganisms have in humans has been characterized only in the case of few bacteria ...
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(Massachusetts Institute of Technology, 2012)High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...
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(Massachusetts Institute of Technology, 2012)In the past decade, thousands of human genomes have been catalogued, either by whole-genome sequencing or by targeted genotyping. The variability between human genomes encodes invaluable information about human traits and ...
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(Massachusetts Institute of Technology, 2012)Metastasis, the spread and growth of tumor cells from the primary site to distant organs, is arguably the most devastating and deadly attribute of cancer, and is ultimately responsible for 90% of cancer-related deaths. ...
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(Massachusetts Institute of Technology, 2012)Over the past ten years there has been increasing public concern regarding the rising costs of pharmaceuticals. Drug expenditure is the fastest growing sector of healthcare costs in the United States. The structure of the ...
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(Massachusetts Institute of Technology, 2012)The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market ...
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(Massachusetts Institute of Technology, 2012)The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ...
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(Massachusetts Institute of Technology, 2012)Articulation of multisyllabic speech requires a high degree of accuracy in controlling the spatial (positional) and the temporal parameters of articulatory movements. In stuttering, a disorder of speech fluency, failures ...
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(Massachusetts Institute of Technology, 2012)Accurate sensory perception in noisy environments requires physiological mechanisms that reduce sensory interference. In the auditory system, it has been hypothesized that attentional control of cochlear responses to sound ...
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(Massachusetts Institute of Technology, 2012)Vertebrate hair cells respond to mechanical stimuli with an inward current that is carried by extracellular cations through mechanically-gated transmembrane ion channels called transduction channels, located in the hair ...
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(Massachusetts Institute of Technology, 2012)The field of medical image analysis continues to expand as magnetic resonance imaging (MRI) technology advances through increases in field strength and the development of new image acquisition and reconstruction methods. ...
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(Massachusetts Institute of Technology, 2012)Hepatitis C (HCV) is the most common bloodborne infection in the United States. Although the incidence of HCV is declining, the burden of the disease is rising, driven by the increasing rates of end-stage liver disease and ...
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