Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Title
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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2008)Sound-evoked vibrations transmitted into the mammalian cochlea produce traveling waves that provide the mechanical tuning necessary for spectral decomposition of sound. These traveling waves of motion propagate along the ...
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(Massachusetts Institute of Technology, 2005)Imaging speed in conventional magnetic resonance imaging (MRI) is limited by the performance of magnetic field gradients and the rate of power deposition in tissue. Parallel MRI techniques overcome these constraints by ...
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(Massachusetts Institute of Technology, 2011)Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine ...
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(Massachusetts Institute of Technology, 2013)Sepsis is a systemic inflammatory response that results the presence and persistence of microorganisms or their toxins in the bloodstream and it is diagnosed by detecting the presence of pathogens in blood. Despite ...
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(Massachusetts Institute of Technology, 2002)This dissertation describes a novel mechanism for the entry of organic cations, including the styryl pyridinium dyes and the notoriously ototo.xic aminoglycoside antibiotic drugs, into sensory hair cells: permeation through ...
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(Massachusetts Institute of Technology, 2008)Metabolic diseases are an increasing health concern in the developed world. Type 2 Diabetes, (T2D) affects over 100 million people worldwide and significantly contributes to chronic diseases such as atherosclerosis and ...
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(Massachusetts Institute of Technology, 2010)Hepatitis C virus (HCV) infection accounts for approximately 40% of chronic liver disease in the United States and results in an estimated 8,000-10,000 deaths annually. Simulations suggest that in the next decade morbidity ...
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A hair bundle proteomics approach to discovering actin regulatory proteins in inner ear stereocilia (Massachusetts Institute of Technology, 2009)Because there is little knowledge in the areas of stereocilia development, maintenance, and function in the hearing system, I decided to pursue a proteomics-based approach to discover proteins that play a role in stereocilia ...
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(Massachusetts Institute of Technology, 1990)
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 2011)Neovascularization is an essential process to repair ischemic tissues following myocardial infarction, stroke, diabetic complications, or transplant procedures. Blood vessels are generated by distinct vasculogenic and ...
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(Massachusetts Institute of Technology, 2000)
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(Massachusetts Institute of Technology, 2012)Humans live in association with trillions of microbes and yet we know remarkably little about their symbiotic relationship. The role these microorganisms have in humans has been characterized only in the case of few bacteria ...
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(Massachusetts Institute of Technology, 2013)The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...
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(Massachusetts Institute of Technology, 2008)The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 1988)
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(Massachusetts Institute of Technology, 2012)In the past decade, thousands of human genomes have been catalogued, either by whole-genome sequencing or by targeted genotyping. The variability between human genomes encodes invaluable information about human traits and ...
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(Massachusetts Institute of Technology, 2010)The innate immune system is the first line of host defense, and its ability to propagate antimicrobial and inflammatory signals from the cellular microenvironment to the tissue at-large is critical for survival. In a ...
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(Massachusetts Institute of Technology, 2012)We searched for genes that are potentially important for the maintenance of Pancreatic Ductal Adenocarcinoma (PDAC). PDAC is the 4th leading cause for cancer-related deaths and exhibits a 5-year survival rate of less than ...
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