Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Title
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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2017)The complex, dynamic, and responsive behavior of cells arises from integrated signaling pathways and regulatory networks. With advancement in our ability to engineer mammalian cells, we harness a novel set of molecular ...
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(Massachusetts Institute of Technology, 2014)Despite the fact that mammalian hair cells and neurons do not naturally regenerate in vivo, progenitor cells exist within the postnatal inner ear that can be manipulated to generate hair cells and neurons. This work reveals ...
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(Massachusetts Institute of Technology, 1987)
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(Massachusetts Institute of Technology, 2015)RNA potently regulates gene expression. However, the utility of RNA has been limited by the ability to efficiently deliver it to specific cells in vivo. In vivo RNA delivery is challenging; vehicles must avoid phagocytosis ...
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(Massachusetts Institute of Technology, 2016)More than 14,000 women in the United States die from ovarian cancer each year. The standard of care is tumor-debulking surgery followed by adjuvant chemotherapy. Combination intraperitoneal (IP) and intravenous (IV) ...
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(Massachusetts Institute of Technology, 2005)Chapter 1. An Introduction to Self-Assembled Monolayers & Surface Characterization A brief summary of the formation, structure, and characterization techniques of self assembled monolayers (SAMs) is described. The ...
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(Massachusetts Institute of Technology, 2007)The main goal of this thesis was to systematically characterize the detection sensitivity, temporal response, and spatial resolution of IRON contrast for fMRI within the awake, behaving monkey. Understanding these issues ...
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(Massachusetts Institute of Technology, 2009)Multi-drug resistant tuberculosis (MDR-TB) patients in resource-poor settings experience large delays in starting appropriate drug regimens and are often not monitored appropriately due to an overburdened health care system, ...
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(Massachusetts Institute of Technology, 2005)Thrombosis is an initiating response to vascular injury. Physiologically, this process aids in the repair and remodeling of the vessel wall. However, if left unchecked, luminal occlusion may rapidly occur. The coronary ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2015)Optical coherence tomography (OCT) allows label-free, three-dimensional imaging of tissue structure. Current implementations of OCT can either image over long depth ranges at slow imaging speeds, or over limited depth ...
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(Massachusetts Institute of Technology, 2014)The BMP signaling pathway is essential for embryonic development and the maintenance of tissue homeostasis. Dysregulated BMP signaling, both loss and gain-of-function, has been demonstrated in the pathogenesis of diseases ...
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(Massachusetts Institute of Technology, 2005)Breast cancer is the most commonly diagnosed cancer among women in the United States. It is the most common cause of death in women ages 45-55. Optical techniques can potentially play a diagnostic role in several aspects ...
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(Massachusetts Institute of Technology, 2003)Cardiovascular disease is the primary cause of mortality in developed nations. Current diagnostic techniques are not able to provide the information that is related to the majority of associated complications. Raman ...
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(Massachusetts Institute of Technology, 2013)Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant ...
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(Massachusetts Institute of Technology, 2009)An Electrolarynx (EL) is a battery-powered device that produces a sound that can be used to acoustically excite the vocal tract as a substitute for laryngeal voice production. ELs provide laryngectomy patients with the ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2002)Magnetic resonance diffusion imaging provides an exquisitely sensitive probe of tissue microstructure. Owing to the microscopic length scale of diffusion in biological tissues, diffusion imaging can reveal histological ...
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(Massachusetts Institute of Technology, 2011)Bone marrow mesenchymal stem cells (MSCs) may soon become the first FDA-approved stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may ...
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The dissection of VEGFA stimulus-responsive regulatory and transcriptional changes in angiogenesis (Massachusetts Institute of Technology, 2015)Several studies over the past decade have transformed our understanding of the regulatory elements and mechanisms utilized by a human cell to drive cell type identity. In particular, epigenomic studies have revealed recurrent ...
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