In addition to cancer cells, solid tumors consist of a variety of cell types and tissues defining a complex microenvironment that influences disease progression and response to therapy. To fully characterize and probe the ...

When viewed under the microscope, biological tissues reveal an exquisite microarchitecture. These complex patterns arise during development, as cells interact with a multitude of chemical and mechanical cues in the surrounding ...

Next-generation DNA sequencing has allowed us to extract vast quantities of functional information from genetic systems. However, natural systems represent only a fraction of all possible DNA sequences. Our understanding ...

The ease of targeted genetic modification makes the mouse a valuable model to study hearing and deafness. A powerful window into cochlear function can be obtained by recording from single auditory (AN) fibers, primary ...

Polyethylene wear is a significant clinical problem limiting the long-term survival of joint replacement prostheses, particularly in total hip arthroplasty (THA) and total knee arthroplasty (TKA). Although the tribology ...

Contamination of food, water, medicine and ingestible household products is a public health hazard that episodically causes outbreaks worldwide. Existing laboratory methods are often expensive, require a laboratory environment ...

Synaptic plasticity is the substrate of a vast variety of learning mechanisms. However, the molecular pathways and physiological patterns that regulate it are poorly understood. In the first part of this thesis, we focus ...

Atherosclerosis is the leading causes of mortality and morbidity in the world. While there are a plethora of methods for treating clinical atherosclerosis, the primary cause of mortality is acute coronary syndrome (ACS) ...