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Electro-chemical stimulation of neuromuscular systems using ion-selective membranes : flexible device fabrication and motor unit recruitment order

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dc.contributor.advisor Jongyoon Han. en_US
dc.contributor.author El Khaja, Ragheb Mohamad Fawaz en_US
dc.contributor.other Massachusetts Institute of Technology. Department of Biological Engineering. en_US
dc.date.accessioned 2013-10-24T17:41:06Z
dc.date.available 2013-10-24T17:41:06Z
dc.date.copyright 2013 en_US
dc.date.issued 2013 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/81663
dc.description Thesis (M. Eng. in Biomedical Engineering)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2013. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (p. 37-40). en_US
dc.description.abstract Spinal Cord injury (SCI) leads to paralysis, decrease in quality of life and high lifetime medical costs. Direct nerve Functional Electrical Stimulation (FES) induces muscles to contract by electrically stimulating nerves, which shows promise for clinical applications in restoring muscle function in SC. However, Functional Electrical Stimulation is limited by the lack of graded response in muscle contraction and by high fatigability due to the reversal of recruitment order of motor units. Previous work showed that ion-selective membranes can be used to modulate Ca 2 ions in situ, decreasing the current threshold for nerve stimulation and eliciting a more graded muscle contraction response. This work developed polyimide-based cuff ion-selective electrodes to enable the future application of this technique in vivo. The developed electrodes were flexible, elastic and conductive. In vitro tests of the electrodes by stimulation of frog sciatic nerve reproduced the decrease in stimulation current threshold, which had been observed in planar glass-based electrodes, in the flexible polyimide-based electrodes. Additionally, cuffing the stimulated nerves with ion-selective electrodes was more effective at decreasing current threshold than planar stimulation. This work also analyzed data on twitch width, contraction time and relaxation time to infer effects of ion-selective electrodes on recruitment order. Stimulation with the ion-selective electrodes had higher twitch width, contraction time and relaxation time than traditional electrical stimulation at all force levels. The difference was particularly high at low force levels, indicating an effect of Calcium ion depletion on recruitment order. en_US
dc.description.statementofresponsibility by Ragheb Mohamad Fawaz El Khaja. en_US
dc.format.extent 40 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Biological Engineering. en_US
dc.title Electro-chemical stimulation of neuromuscular systems using ion-selective membranes : flexible device fabrication and motor unit recruitment order en_US
dc.type Thesis en_US
dc.description.degree M.Eng.in Biomedical Engineering en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biological Engineering. en_US
dc.identifier.oclc 859872619 en_US


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