The Genotype-Tissue Expression (GTEx) project
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Kellis_The genotype-tissue.pdf
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568.78 KB
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Adobe PDF
Checksum (MD5)
e7d7edcb578a2965a183552967e570c1
Author(s)
Kellis, Manolis
Date Issued
May 2013
Journal
Nature Genetics
Publisher
Nature Publishing Group
Citation
Lonsdale, John, Jeffrey Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz, et al. “The Genotype-Tissue Expression (GTEx) Project.” Nature Genetics 45, no. 6 (May 29, 2013): 580–585.
Version
Author's final manuscript
Abstract
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/ng.2653
