| dc.contributor.author | Laplante, Mathieu | |
| dc.contributor.author | Sabatini, David M. | |
| dc.contributor.author | Sabatini, David | |
| dc.date.accessioned | 2014-11-24T19:15:02Z | |
| dc.date.available | 2014-11-24T19:15:02Z | |
| dc.date.issued | 2012-04 | |
| dc.identifier.issn | 00928674 | |
| dc.identifier.issn | 1097-4172 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/91891 | |
| dc.description.abstract | The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) | en_US |
| dc.description.sponsorship | Howard Hughes Medical Institute | en_US |
| dc.description.sponsorship | United States. Dept. of Defense | en_US |
| dc.description.sponsorship | Whitehead Institute for Biomedical Research | en_US |
| dc.description.sponsorship | Canadian Institutes of Health Research (Fellowship) | en_US |
| dc.description.sponsorship | Fonds de la recherche en santé du Québec (Fellowship) | en_US |
| dc.description.sponsorship | W. M. Keck Foundation | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.cell.2012.03.017 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Elsevier | en_US |
| dc.title | mTOR Signaling in Growth Control and Disease | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Laplante, Mathieu, and David M. Sabatini. “mTOR Signaling in Growth Control and Disease.” Cell 149, no. 2 (April 2012): 274–293. © 2012 Elsevier Inc. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Whitehead Institute for Biomedical Research | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Laplante, Mathieu | en_US |
| dc.contributor.mitauthor | Sabatini, David M. | en_US |
| dc.relation.journal | Cell | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Laplante, Mathieu; Sabatini, David M. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-1446-7256 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
