Show simple item record

Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

dc.contributor.authorWisnovsky, Simon P.
dc.contributor.authorWilson, Justin J.
dc.contributor.authorRadford, Robert J.
dc.contributor.authorPereira, Mark P.
dc.contributor.authorChan, Maria R.
dc.contributor.authorLaposa, Rebecca R.
dc.contributor.authorLippard, Stephen J.
dc.contributor.authorKelley, Shana O.
dc.date.accessioned2015-02-24T15:31:09Z
dc.date.available2015-02-24T15:31:09Z
dc.date.issued2013-10
dc.date.submitted2013-08
dc.identifier.issn10745521
dc.identifier.urihttp://hdl.handle.net/1721.1/95474
dc.description.abstractAn analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Grant CA034992)en_US
dc.description.sponsorshipDavid H. Koch Graduate Fellowshipen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.chembiol.2013.08.010en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevier Open Archiveen_US
dc.titleTargeting Mitochondrial DNA with a Platinum-Based Anticancer Agenten_US
dc.typeArticleen_US
dc.identifier.citationWisnovsky, Simon P., Justin J. Wilson, Robert J. Radford, Mark P. Pereira, Maria R. Chan, Rebecca R. Laposa, Stephen J. Lippard, and Shana O. Kelley. “Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent.” Chemistry & Biology 20, no. 11 (November 2013): 1323–1328. © 2013 Elsevier Ltd.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorWilson, Justin J.en_US
dc.contributor.mitauthorRadford, Robert J.en_US
dc.contributor.mitauthorChan, Maria R.en_US
dc.contributor.mitauthorLippard, Stephen J.en_US
dc.relation.journalChemistry and Biologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWisnovsky, Simon P.; Wilson, Justin J.; Radford, Robert J.; Pereira, Mark P.; Chan, Maria R.; Laposa, Rebecca R.; Lippard, Stephen J.; Kelley, Shana O.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


Files in this item

Thumbnail
Name:
Lippard_Targeting mitochondrial.pdf
Size:
1.064Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record