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This is an archived course. A more recent version may be available at ocw.mit.edu.
Model pathway for a newly synthesized polypeptide chain emerging from the ribosome and folding to its native state, as well as an off-pathway inactive aggregated state. (Image by Prof. Jonathan King.)
Prof. Jonathan King
7.88J / 7.24J / 5.48J / 10.543J
Fall 2007
Undergraduate / Graduate
This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.
OCW has published multiple versions of this subject. 
Archived versions: 
Jonathan King. 7.88J Protein Folding Problem. Fall 2007. Massachusetts Institute of Technology: MIT OpenCourseWare, https://ocw.mit.edu. License: Creative Commons BY-NC-SA.
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