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The course textbook by Prof. Grodzinsky (Fields, Forces and Flows in Biological Systems) was provided to students as an unpublished manuscript.
References to "Deen" below are from the text Deen, W. M. Analysis of Transport Phenomena. New York: Oxford University Press, 1998. ISBN: 0195084942.
Table for Calendar
| L1 |
Introduction/Summary
Examples |
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."
Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. |
| I. Chemical Subsystem |
| L2 |
Continuity of Chemical Species, Flux, Reaction Rates, Boundary Conditions |
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."
Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. |
| L3 |
Diffusion
Begin Reaction
Damkohler #
Scaling and Approximations |
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."
Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. |
| L4 |
Example Problems: Separation of Variables Method |
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."
Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. |
| L5 |
Example Problems: Separation of Variables Method (cont.)
Case Study: IGF Problem from Lecture L1 using Matrix Continuum Distribution of IGF Binding Proteins
Numerical Considerations (if time) |
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."
Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. |
| III. Cellular Applications |
| L14 |
Experimental Methods |
Paper for discussion: Graff, C., and D. Wittrup. "Theoretical Analysis of Antibody Targeting of Tumor Spheroids: Importance of Dosage for Penetration, and Affinity for Retention." Cancer Res 2003. |
| L15 |
Ligand Binding to Cell Receptors |
Paper for discussion: Haugh, et. al. "Spatial Sensing in Fibroblasts Mediated by 3' Phosphoinositides." J Cell Biol. 151, no. 6 (2000): 1269.
———. "Online Supplemental Material." J. Cell Biol. 151, no. 6 (2000). |