Now showing items 1-2 of 2

    • Engineering and optimising deaminase fusions for genome editing 

      Yang, Luhan; Briggs, Adrian W.; Chew, Wei Leong; Mali, Prashant; Guell, Marc; e.a. (Nature Publishing Group, 2016-11)
      Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. ...
    • Highly efficient Cas9-mediated transcriptional programming 

      Chavez, Alejandro; Scheiman, Jonathan; Tuttle, Marcelle; Lin, Shuailiang; Kiani, Samira; e.a. (Nature Publishing Group, 2015-03)
      The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription factor. However, modest levels of gene activation have limited potential applications. We describe an improved transcriptional regulator ...