Browsing by Title
Now showing items 100560-100579 of 111396
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T cell mediated combination immunotherapy
(Massachusetts Institute of Technology, 2016)Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the ... -
T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis
(Elsevier, 2011-08)The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated ... -
A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
(Massachusetts Institute of Technology, 1999)CDS+ T lymphocytes recognize short peptide fragments when bound to self-class I major histocompatibility proteins. On a mature lymphocyte, such recognition results in activation of the T cell. On an immature thymocyte, ... -
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
(Nature Publishing Group, 2017-11)Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited benefit, we ... -
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
(Elsevier Science Ltd., 2018-11-15)In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC ... -
T Talk : a local communication channel for subway riders
(Massachusetts Institute of Technology, 2007)The goal of T Talk, is to utilize the tens of minutes of subway waiting time everyday as an opportunity for reading and appreciation of the complexity and diversity of the city, and developing an awareness of and social ... -
T(ether): spatially-aware handhelds, gestures and proprioception for multi-user 3D modeling and animation
(2014-10)T(ether) is a spatially-aware display system for multi-user, collaborative manipulation and animation of virtual 3D objects. The handheld display acts as a window into virtual reality, providing users with a perspective ... -
T(T,2n)[superscript 4]He and [superscript 3]He([superscript 3]He,2p)[superscript 4]He: The Reaction Mechanism from Solar Energies to 10 MeV*
(EDP Sciences, 2016-03)We have studied the energy dependence of the reaction mechanism of the T(t,2n)[superscript 4] He reaction at stellar energies and of its charge symmetric analog reaction [superscript 3]He([superscript 3]He,2p)[superscript ... -
T-cell death following immune activation is mediated by mitochondria-localized SARM
(Nature Publishing Group, 2012-11)Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif ... -
T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell
(National Academy of Sciences (U.S.), 2010-11)The conversion of mature somatic cells into pluripotent stem cells, both by nuclear transfer and transduction with specific “reprogramming” genes, represents a major advance in regenerative medicine. Pluripotent stem cell ... -
T-duality constraints on higher derivatives revisited
(Springer Berlin Heidelberg, 2016-04)We ask to what extent are the higher-derivative corrections of string theory constrained by T-duality. The seminal early work by Meissner tests T-duality by reduction to one dimension using a distinguished choice of field ... -
T-junction resonant modulators and detectors in CMOS
(Massachusetts Institute of Technology, 2016)Design of optical modulators and detectors is investigated. A new design idea is proposed for optical modulators - T-junction. The T-junction allows to decouple the Extinction Ratio from the Bandwidth and to optimize each ... -
T1 scaling : a mathematical programming approach to Thurstonian scaling
(Cambridge, Mass. : Alfred P. Sloan School of Management, Massachusetts Institute of Technology, 1981) -
TABASCO: A single molecule, base-pair resolved gene expression simulator
(BioMed Central Ltd, 2007-12)Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ... -
TablaNet : a real-time online musical collaboration system for Indian percussion
(Massachusetts Institute of Technology, 2007)Thanks to the Internet, musicians located in different countries can now aspire to play with each other almost as if they were in the same room. However, the time delays due to the inherent latency in computer networks (up ... -
Table 1 (Supplemental): Summary of expression programs discovered by GeneProgram from Novartis Tissue Atlas v2 data
(2007-06-25)Table 1 (Supplemental): Summary of recurrent expression programs (EPs) discovered by GeneProgram. The columns are: (1) the EP identifier (an arbitrarily assigned number), (2) the number of genes in the EP, (3) the number ... -
Table 2 (Supplemental): Complete data for all 100 expression programs discovered by GeneProgram from the Novartis Gene Atlas v2
(2007-06-25)Table 2 (Supplemental): Complete data for all 100 recurrent expression programs (EPs) discovered by GeneProgram. Each EP has two identifying rows, a list of meta-genes, and a list of significantly enriched GO categories. ... -
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(Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1949-07-15) -
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(Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1949-01-15) -
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(Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1946-10-15)
