Browsing by Title
Now showing items 83596-83615 of 142684
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Molecular Assembly-Induced Charge Transfer for Programmable Functionalities
(American Chemical Society (ACS), 2017)© 2017 American Chemical Society. The donor-acceptor interface within molecular charge transfer (CT) solids plays a vital role in the hybridization of molecular orbitals to determine their carrier transport and electronic ... -
Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli
(eLife Sciences Publications, Ltd., 2016-01)Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, ... -
Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme
(eLife Sciences Publications, Ltd, 2020-03)The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline ... -
Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513
(Nature Publishing Group, 2018-05)Dengue is a widespread viral disease with 3.6 billion people at risk worldwide. Humanized monoclonal antibody (mAb) 513, currently undergoing clinical trials in Singapore, targets an epitope on the envelope protein domain ... -
Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex
(National Academy of Sciences (U.S.), 2012-09)Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of ∼30 different proteins called nucleoporins. To unravel the basic scaffold underlying the NPC, we ... -
Molecular Basis for Self-Assembly of a Human Host-Defense Peptide That Entraps Bacterial Pathogens
(American Chemical Society (ACS), 2014-08)Human α-defensin 6 (HD6) is a 32-aa cysteine-rich peptide of the innate immune system. Although HD6 is a member of an antimicrobial peptide family, it exhibits negligible antibacterial activity in vitro. Rather, HD6 possesses ... -
Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins
(Elsevier, 2012-07)Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor ... -
The molecular basis for tumor growth suppression by tRNA methyltransferase 9-like (TRM9L)
(Massachusetts Institute of Technology, 2017)The human tRNA methyltransferase 9-like (TRM9L) gene is a homolog of yeast Trm9 and human ALKBH8 and it has an important function in suppressing tumor growth in colorectal cancer. Loss of heterozygosity events on the ... -
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
(Elsevier BV, 2021)Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen ... -
Molecular Basis of Ca(II)-Induced Tetramerization and Transition-Metal Sequestration in Human Calprotectin
(American Chemical Society (ACS), 2021)Human calprotectin (CP, S100A8/S100A9 oligomer, MRP8/MRP14 oligomer) is an abundant innate immune protein that contributes to the host metal-withholding response. Its ability to sequester transition metal nutrients from ... -
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism
(Nature Publishing Group, 2016-04)Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and ... -
Molecular basis of cobalamin-dependent RNA modification
(Oxford University Press, 2016-09)Queuosine (Q) was discovered in the wobble position of a transfer RNA (tRNA) 47 years ago, yet the final biosynthetic enzyme responsible for Q-maturation, epoxyqueuosine (oQ) reductase (QueG), was only recently identified. ... -
Molecular basis of CTCF binding polarity in genome folding
(Springer Science and Business Media LLC, 2020)© 2020, The Author(s). Current models propose that boundaries of mammalian topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. While the ... -
Molecular Basis of C–N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase
(Elsevier BV, 2016-09)Deamination of choline catalyzed by the glycyl radical enzyme choline trimethylamine-lyase (CutC) has emerged as an important route for the production of trimethylamine, a microbial metabolite associated with both human ... -
The molecular basis of LINC complex formation
(Massachusetts Institute of Technology, 2014)The nucleus is the hallmark of the eukaryotic cell. It contains most of the genetic material and it separates the processes of replication and transcription from that of translation. Communication between the nucleus and ... -
Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase
(Springer Science and Business Media LLC, 2018-11)Osm1 and Frd1 are soluble fumarate reductases from yeast that are critical for allowing survival under anaerobic conditions. Although they maintain redox balance during anaerobiosis, the underlying mechanism is not understood. ... -
The molecular basis of pancreatic amyloid deposition in type II diabetes and the binding of congo red to amyloid
(Massachusetts Institute of Technology, 1995) -
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS
(United States National Academy of Sciences, 2009-04)The N-end rule is a conserved degradation pathway that relates the stability of a protein to its N-terminal amino acid. Here, we present crystal structures of ClpS, the bacterial N-end rule adaptor, alone and engaged with ... -
Molecular beam epitaxial growth and charcterization of mismatched InGaAs and InAlAs layers on InP
(Massachusetts Institute of Technology, 1993) -
Molecular beam epitaxy growth of antiferromagnetic Kagome metal FeSn
(AIP Publishing, 2019-08)FeSn is a room-temperature antiferromagnet expected to host Dirac fermions in its electronic structure. The interplay of the magnetic degree of freedom and the Dirac fermions makes FeSn an attractive platform for spintronics ...
