Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions
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Goard-2016-Distinct roles of vi.pdf
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7.99 MB
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Author(s)
Goard, Michael
Pho, Gerald N
Woodson, Jonathan
Sur, Mriganka
Date Issued
August 2016
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Goard, Michael J., Gerald N. Pho, Jonathan Woodson, and Mriganka Sur. “Distinct Roles of Visual, Parietal, and Frontal Motor Cortices in Memory-Guided Sensorimotor Decisions.” eLife, 5, August 2016, pp. 1-30.
Version
Final published version
Abstract
Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memory-guided visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). Population analyses demonstrated unique encoding of stimulus identity and behavioral choice information across regions, with V1 encoding stimulus, fMC encoding choice even early in the trial, and PPC multiplexing the two variables. Optogenetic inhibition during behavior revealed that all regions were necessary during the stimulus epoch, but only fMC was required during the delay and response epochs. Stimulus identity can thus be rapidly transformed into behavioral choice, requiring V1, PPC, and fMC during the transformation period, but only fMC for maintaining the choice in memory prior to execution.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/eLife.13764
