Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
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Su-2014-Palladium-catalyzed.pdf
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Author(s)
Su, Mingjuan
Hoshiya, Naoyuki
Buchwald, Stephen Leffler
Date Issued
January 2014
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Su, Mingjuan, Naoyuki Hoshiya, and Stephen L. Buchwald. “Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides.” Org. Lett. 16, no. 3 (February 7, 2014): 832–835. © 2014 American Chemical Society
Version
Final published version
Abstract
An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reaction conditions employed allow for the preparation of a broad scope of aminoimidazoles and aminopyrazoles in moderate to excellent yields.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol4035947
