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Viewing Nuclear Architecture through the Eyes of Nocturnal Mammals
Name
nihms-1569406.pdf
Description
Accepted version
Size
1.31 MB
Format
Adobe PDF
Checksum (MD5)
97dddbeee4e18cf505d213028f48350d
Author(s)
Feodorova, Yana
Falk, Martin
Mirny, Leonid A
Solovei, Irina
Date Issued
2020
Journal
Trends in Cell Biology
Publisher
Elsevier BV
Citation
Feodorova, Yana, Falk, Martin, Mirny, Leonid A and Solovei, Irina. 2020. "Viewing Nuclear Architecture through the Eyes of Nocturnal Mammals." Trends in Cell Biology, 30 (4).
Version
Author's final manuscript
Abstract
© 2019 Elsevier Ltd The cell nucleus is a remarkably well-organized organelle with membraneless but distinct compartments of various functions. The largest of them, euchromatin and heterochromatin, are spatially segregated in such a way that the transcriptionally active genome occupies the nuclear interior, whereas silent genomic loci are preferentially associated with the nuclear envelope. This rule is broken by rod photoreceptor cells of nocturnal mammals, in which the two major compartments have inverted positions. The inversion and dense compaction of heterochromatin converts these nuclei into microlenses that focus light and facilitate nocturnal vision. As is often the case in biology, when a mutation helps to understand normal processes and structures, inverted nuclei have served as a tool to unravel general principles of nuclear organization, including mechanisms of heterochromatin tethering to the nuclear envelope, autonomous behavior of small genomic segments, and euchromatin–heterochromatin segregation.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.TCB.2019.12.008
