Algorithms for simulating human pre-mRNA splicing decisions
Name
82538091-MIT.pdf
Description
Full printable version
Size
1.72 MB
Format
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Checksum (MD5)
8d62e697a5e925b7adaf163942cc6405
Author(s)
Rolish, Michael E. (Michael Edward)
Advisor(s)
Christopher B. Burge.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
In this thesis, I developed a program, ExonScan, to simulate constitutive human pre-mRNA splicing. ExonScan includes several models for splicing components, including splice sites, exonic splicing enhancers, exonic splicing silencers, and intronic splicing enhancers. I used ExonScan to test various aspects of human splicing, including correlation of splicing signal strength with tissue expression levels, the effectiveness of experimentally determined exonic splicing silencers, and splice site identification.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
Includes bibliographical references (leaves 37-38).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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