Reward-Sensitive Basal Ganglia Stabilize the Maintenance of Goal-Relevant Neural Patterns in Adolescents
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jocn_a_01572.pdf
Description
Published version
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750.14 KB
Format
Adobe PDF
Checksum (MD5)
81972e8dccc5a4e087e7e45eeba9721f
Author(s)
Hubbard, Nicholas A
Romeo, Rachel R
Grotzinger, Hannah
Giebler, Melissa
Imhof, Andrea
Bauer, Clemens CC
Gabrieli, John DE
Date Issued
2020
Journal
Journal of Cognitive Neuroscience
Publisher
MIT Press - Journals
Version
Final published version
Abstract
© MIT Press Journals. All rights reserved. Maturation of basal ganglia (BG) and frontoparietal circuitry parallels developmental gains in working memory ( WM). Neurobiological models posit that adult WM performance is enhanced by communication between reward-sensitive BG and frontoparietal regions, via increased stability in the maintenance of goal-relevant neural patterns. It is not known whether this reward-driven pattern stability mechanism may have a role in WM development. In 34 young adolescents (12.16–14.72 years old) undergoing fMRI, reward-sensitive BG regions were localized using an incentive processing task. WM-sensitive regions were localized using a delayed-response WM task. Functional connectivity analyses were used to examine the stability of goal-relevant functional connectivity patterns during WM delay periods between and within reward-sensitive BG and WM-sensitive frontoparietal regions. Analyses revealed that more stable goal-relevant connectivity patterns between reward-sensitive BG and WM-sensitive frontoparietal regions were associated with both greater adolescent age and WM ability. Computational lesion models also revealed that functional connections to WM-sensitive frontoparietal regions from reward-sensitive BG uniquely increased the stability of goal-relevant functional connectivity patterns within frontoparietal regions. Findings suggested (1) the extent to which goal-rel evant communi cat i on pat t er ns wi t hi n r ewar d-frontoparietal circuitry are maintained increases with adolescent development and WM ability and (2) communication from reward-sensitive BG to frontoparietal regions enhances the maintenance of goal-relevant neural patterns in adoles-cents’ WM. The maturation of reward-driven stability of goal-relevant neural patterns may provide a putative mechanism for understanding the developmental enhancement of WM.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
10.1162/JOCN_A_01572
https://doi.org/10.1162/JOCN_A_01572
