A cerebellar mechanism for learning prior distributions of time intervals
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s41467-017-02516-x.pdf
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Author(s)
Zeeuw, Chris I. De
Narain, Devika
Remington, Evan D
Jazayeri, Mehrdad
Date Issued
February 2018
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Narain, Devika et al. “A Cerebellar Mechanism for Learning Prior Distributions of Time Intervals.” Nature Communications 9, 1 (February 2018) © 2018 The Author(s)
Version
Final published version
Abstract
Knowledge about the statistical regularities of the world is essential for cognitive and sensorimotor function. In the domain of timing, prior statistics are crucial for optimal prediction, adaptation and planning. Where and how the nervous system encodes temporal statistics is, however, not known. Based on physiological and anatomical evidence for cerebellar learning, we develop a computational model that demonstrates how the cerebellum could learn prior distributions of time intervals and support Bayesian temporal estimation. The model shows that salient features observed in human Bayesian time interval estimates can be readily captured by learning in the cerebellar cortex and circuit level computations in the cerebellar deep nuclei. We test human behavior in two cerebellar timing tasks and find prior-dependent biases in timing that are consistent with the predictions of the cerebellar model.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Terms of Use
Attribution 4.0 International (CC BY 4.0)
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41467-017-02516-x
