Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source
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Bagley_2013-Plasmonic photothermal heating.pdf
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Author(s)
Bagley, Alexander F.
Hill, Samuel
Rogers, Gary S.
Bhatia, Sangeeta N.
Date Issued
August 2013
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Bagley, Alexander F., Samuel Hill, Gary S. Rogers, and Sangeeta N. Bhatia. “Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source.” ACS Nano 7, no. 9 (September 24, 2013): 8089-8097. © 2013 American Chemical Society
Version
Final published version
Abstract
Plasmonic nanomaterials including gold nanorods are effective agents for inducing heating in tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. For more complex models of disease such as advanced ovarian cancer, one of the primary barriers to gold nanorod-based strategies is the adequate delivery of NIR light to tumors located at varying depths within the body. To address this limitation, a series of implanted NIR illumination sources are described for the specific heating of gold nanorod-containing tissues. Through computational modeling and ex vivo studies, a candidate device is identified and validated in a model of orthotopic ovarian cancer. As the therapeutic, imaging, and diagnostic applications of plasmonic nanomaterials progress, effective methods for NIR light delivery to challenging anatomical regions will complement ongoing efforts to advance plasmonic photothermal therapy toward clinical use.
MIT Department
Whitaker College of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
http://dx.doi.org/10.1021/nn4033757
