Kinetochore assembly: if you build it, they will come
Name
Cheeseman_Kinetochore assembly.pdf
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150.68 KB
Format
Adobe PDF
Checksum (MD5)
3a413e7a4900b48c5f6e09a69027beb1
Author(s)
Gascoigne, Karen E
Cheeseman, Iain M
Date Issued
August 2010
Journal
Current Opinion in Cell Biology
Publisher
Elsevier
Citation
Gascoigne, Karen E, and Iain M Cheeseman. “Kinetochore Assembly: If You Build It, They Will Come.” Current Opinion in Cell Biology 23, no. 1 (February 2011): 102–108.
Version
Author's final manuscript
Abstract
Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from the mitotic spindle. This interaction is mediated by the macro-molecular kinetochore complex, which assembles only at the centromeric region of each chromosome. However, how this site is specified and how assembly of the kinetochore structure is regulated in coordination with cell cycle progression remains unclear. Recent studies have begun to shed light on the mechanisms underlying assembly of this complex structure.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-Noncommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.ceb.2010.07.007
