Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions
Name
Feng-shengf-phd-chemistry-2022-thesis.pdf
Description
Thesis PDF
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18.38 MB
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Adobe PDF
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Author(s)
Feng, Sheng
Advisor(s)
Buchwald, Stephen L.
Date Issued
May 2022
Publisher
Massachusetts Institute of Technology
Abstract
The work described in this dissertation focuses on developing copper(I) hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. The third chapter demonstrates the enantioselective hydrocarbamoylation of alkenes enable by dual CuH and Pd catalysis.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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