Size adjustable separation of biologically active molecules
Name
69017801-MIT.pdf
Description
Full printable version
Size
11 MB
Format
Adobe PDF
Checksum (MD5)
96cf06ebede25731385939e52467baea
Author(s)
Gutierrez, Mauricio R. (Mauricio Roberto)
Advisor(s)
Kamal Youcef-Toumi.
Date Issued
2004
Publisher
Massachusetts Institute of Technology
Abstract
Separation of biologically active molecules (BAM's) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to filter desired materials. As a result, a new technology is needed. The objective of this thesis is to contribute towards the development of a new method for separating biologically active molecules in the size range of 0.5 nanometers to 500 nanometers. A normally open diaphragm valve is proposed that can control a gap formed by two flat surfaces. For accurate control of gap height, the valve was designed to ensure that the flat surfaces remain parallel during operation . Modularity was also part of design considerations to address issues of eventual biocompatibility breakdown specifically protein adsorption. Control of the gap has been achieved to increments of 1.8 nanometers.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.
Includes bibliographical references (p. 92-96).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
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