Ampli: A Construction Set for Paperfluidic Systems
Name
ampli_jan25_2018_gomez_marquez.pdf
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4.64 MB
Format
Adobe PDF
Checksum (MD5)
97040e2425edb4f9fa314e46ba776c50
Author(s)
Phillips, Elizabeth A.
Young, Anna K.
Albarran, Nikolas A.
Butler, Jonah
Lujan, Kaira
Hamad-Schifferli, Kimberly
Gomez-Marquez, Jose Zacapa
Date Issued
May 2018
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Phillips, Elizabeth A. et al. "Ampli: A Construction Set for Paperfluidic Systems." Advanced Healthcare Materials, 7, (May 2018): 1800104 © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Version
Author's final manuscript
Abstract
The design and fabrication of reconfigurable, modular paperfluidics driven by a prefabricated reusable block library, asynchronous modular paperfluidic linear instrument‐free (Ampli) block, are reported. The blocks are inspired by the plug‐and‐play modularity of electronic breadboards that lower prototyping barriers in circuit design. The resulting biochemical breadboard is a paperfluidic construction set that can be functionalized with chemical, biological, and electrical elements. Ampli blocks can form standard paperfluidic devices without any external instrumentation. Furthermore, their modular nature enhances fluidics in ways that fixed devices cannot. The blocks' ability to start, stop, modify, and reverse reaction flows, reagents, and rates in real time is demonstrated. These enhancements allow users to increase colorimetric signals, fine tune reaction times, and counter check multiplexed diagnostics for false positives or negatives. The modular construction demonstrates that field‐ready, distributed fabrication of paper analytical systems can be standardized without requiring the “black box” of craft and technique inherent in paper‐based systems. Ampli assembly and point‐of‐care redesign extends the usability of paper analytical systems and invites user‐driven prototyping beyond the lab setting demonstrating “Design for Hack” in diagnostics. Keyword: Pharmaceutical Science; Biomaterials; Biomedical Engineering
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
SUTD-MIT International Design Centre (IDC)
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.201800104
