Long non-coding RNAs as regulators of the endocrine system
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nihms671909.pdf
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Author(s)
Sun, Lei
Knoll, Marko
Lodish, Harvey F
Date Issued
January 2015
Journal
Nature Reviews Endocrinology
Publisher
Nature Publishing Group
Citation
Knoll, Marko et al. “Long Non-Coding RNAs as Regulators of the Endocrine System.” Nature Reviews Endocrinology 11, 3 (January 2015): 151–160 © 2015 Macmillan Publishers Limited
Version
Author's final manuscript
Abstract
Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments and establish active or repressive chromatin states; others are cytosolic and regulate the stability of mRNA or act as microRNA sponges. This Review summarizes the current knowledge of lncRNAs as regulators of the endocrine system, with a focus on the identification and mode of action of several endocrine-important lncRNAs. We highlight lncRNAs that have a role in the development and function of pancreatic β cells, white and brown adipose tissue, and other endocrine organs, and discuss the involvement of these molecules in endocrine dysfunction (for example, diabetes mellitus). We also address the associations of lncRNAs with nuclear receptors involved in major hormonal signalling pathways, such as estrogen and androgen receptors, and the relevance of these associations in certain endocrine cancers.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/NRENDO.2014.229
