Effect of Column Inlet and Outlet Geometry on Large-scale HPLC
Name
HPCES008.pdf
Size
375.62 KB
Format
Adobe PDF
Checksum (MD5)
cdc4b538fc7b3bab5fc29659e13acfb4
Author(s)
Tan, S.N.
Khoo, Boo Cheong
Date Issued
January 2003
Series/Report no.
High Performance Computation for Engineered Systems (HPCES);
Abstract
The separating characteristics of high performance liquid chromatography (HPLC) columns, measured in terms of the height equivalent of a theoretical plate (HETP) and skewness of the eluted peak, are investigated using computational fluid dynamics (CFD). Gradually expanding and contracting sections are introduced at the inlet and outlet, respectively, in columns with and without frits and their performance was compared with that of the conventional columns without expanding and contracting regions.
Subjects
column efficiency
computational fluid dynamics
FLUENT
Frit quality
liquid chromatography
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