Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells
Name
Shu-2009-Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells.pdf
Size
3.82 MB
Format
Adobe PDF
Checksum (MD5)
6b867b41aa177691f4f2f771c88dfead
Author(s)
Shu, K.
Thatte, H.
Spector, Myron
Date Issued
May 2009
Journal
IEEE 35th Annual Northeast Bioengineering Conference, 2009
Publisher
Institute of Electrical and Electronics Engineers
Citation
Shu, K., H. Thatte, and M. Spector. “Chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells.” Bioengineering Conference, 2009 IEEE 35th Annual Northeast. 2009. 1-2. © 2009 IEEE.
Version
Final published version
Abstract
Mesenchymal stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were compared for cartilage histogensis. Both cell types expressed alpha-SMA in monolayer. However, when cultured in pellets and in 3-D scaffolds, only MSCs contracted and formed glycosaminoglycan (GAG)- and type II collagen-rich tissue. Under these culture conditions, MSCs appear to be superior over ECCs for cartilage regeneration.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/NEBC.2009.4967739
