Nationwide Trends in Hospitalizations for Sudden Cardiac Arrest Before and During the COVID Outbreak
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jcm-14-07517.pdf
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1.03 MB
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Checksum (MD5)
311f4f996c0ada576546871c5a07d057
Author(s)
Daoudi, Sarah
Furer, Ariel
John, Kevin
Chalhoub, Fadi
Chee, Jennifer
Infeld, Margaret
Elbaz-Greener, Gabby
Homoud, Munther
Udelson, James
Madias, Christopher
Date Issued
October 22, 2025
Journal
Journal of Clinical Medicine
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Daoudi, S., Furer, A., John, K., Chalhoub, F., Chee, J., Infeld, M., Elbaz-Greener, G., Homoud, M., Udelson, J., Madias, C., & Rozen, G. (2025). Nationwide Trends in Hospitalizations for Sudden Cardiac Arrest Before and During the COVID Outbreak. Journal of Clinical Medicine, 14(21), 7517.
Version
Final published version
Abstract
Background/Objectives: Sudden cardiac arrest (SCA) accounts for ~50% of cardiovascular mortality in the U.S. Cardiovascular complications are common in acute and post-acute COVID-19 infection. We aimed to examine nationwide trends in SCA-related hospitalizations in the United States before and during the COVID-19 outbreak. Methods: Using data from the National Inpatient Sample, we conducted a retrospective analysis of hospitalizations for SCA in the U.S. between 2016 and 2020. Sociodemographic and clinical characteristics and in-hospital mortality were compared between the pre-COVID (2016– 2019) and COVID (2020) eras. Multivariable analysis was performed to identify factors associated with mortality. Results: Among a weighted total of 153,100 SCA hospitalizations between 2016 and 2020, the median age was 65 years, 62.7% were male, and 66.6% were white. There was a trend towards fewer hospitalizations in 2020 compared to prior years (n = 28,585 vs. naverage = 32,129, p = 0.07). In-hospital mortality remained unchanged between the pre-COVID and COVID eras (47.7% vs. 47.3%, p = 0.66). Increased mortality was associated with female sex (OR: 1.21; 95% CI: 1.15–1.28; p < 0.001), non-white race (OR: 1.24; 95% CI: 1.15–1.28; p < 0.001), history of renal failure (OR: 1.08; 95% CI: 1.02–1.15; p = 0.007), and diabetes (OR: 1.32; 95% CI: 1.25–1.39; p < 0.001). In 2020, 1.5% of the study population was diagnosed with COVID-19 infection, which was found to be independently associated with increased in-hospital mortality (OR: 1.57; 95% CI: 1.27–1.95; p < 0.001). Conclusions: In 2020, there was a trend towards a decrease in hospitalizations for SCA, while COVID-19 infection was independently associated with higher in-hospital mortality among patients admitted with SCA.
MIT Department
Institute for Medical Engineering and Science
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/jcm14217517
