Temporal coding and rate remapping: Representation of nonspatial information in the hippocampus
Name
hipo.23020.pdf
Description
Accepted version
Size
1.76 MB
Format
Adobe PDF
Checksum (MD5)
c7482ea215ed1121d595724efd7c565d
Author(s)
Sanders, Honi
Ji, Daoyun
Sasaki, Takuya
Leutgeb, Jill K.
Wilson, Matthew A.
Lisman, John E.
Date Issued
November 2018
Journal
Hippocampus
Publisher
Wiley
Citation
Sanders, Honi et al. "Temporal coding and rate remapping: Representation of nonspatial information in the hippocampus." Hippocampus 29, 2 (November 2018) © 2018 Wiley Periodicals, Inc
Version
Author's final manuscript
Abstract
Hippocampal place cells represent nonspatial information through a process called rate remapping, which involves a change in the firing rate of a place cell without changes in its spatial specificity. However, many hippocampal phenomena occur on very short time scales over which long-term average firing rates are not an appropriate description of activity. To understand how rate remapping relates to fine-scale temporal firing phenomena, we asked how rate remapping affected burst firing and trial-to-trial spike count variability. In addition, we looked at how rate remapping relates to the theta-frequency oscillations of the hippocampus, which are thought to temporally organize firing on time scales faster than 100 ms. We found that theta phase coding was preserved through changes in firing rate due to rate remapping. Interestingly, rate remapping in CA1 in response to task demands preferentially occurred during the first half of the theta cycle. The other half of the theta cycle contained preferential expression of phase precession, a phenomenon associated with place cell sequences, in agreement with previous results. This difference of place cell coding during different halves of the theta cycle supports recent theoretical suggestions that different processes occur during the two halves of the theta cycle. The differentiation between the halves of the theta cycle was not clear in recordings from CA3 during rate remapping induced by task-irrelevant sensory changes. These findings provide new insight into the way that temporal coding is utilized in the hippocampus and how rate remapping is expressed through that temporal code. Keywords: overdispersion; phase precession; place cells; theta rhythm; theta sequence
MIT Department
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/hipo.23020
