GABA Neurons of the VTA Drive Conditioned Place Aversion
Name
Tan-2012-GABA Neurons of the.pdf
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1.53 MB
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Author(s)
Tan, Kelly R.
Turiault, Marc
Mirzabekov, Julie J.
Doehner, Jana
Deisseroth, Karl
Tye, Kay
Yvon, Cedric
Labouebe, Gwenael
Luscher, Christian
Date Issued
March 2012
Journal
Neuron
Publisher
Elsevier
Citation
Tan, Kelly R., Cedric Yvon, Marc Turiault, Julie J. Mirzabekov, Jana Doehner, Gwenael Labouebe, Karl Deisseroth, Kay M. Tye, and Christian Luscher. “GABA Neurons of the VTA Drive Conditioned Place Aversion.” Neuron 73, no. 6 (March 2012): 1173–1183. © 2012 Elsevier Inc.
Version
Final published version
Abstract
Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA[subscript A] receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2012.02.015
