Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold
Name
nihms589761.pdf
Description
Accepted version
Size
2.14 MB
Format
Adobe PDF
Checksum (MD5)
186a8836b87f8bd69f50263eb92820d3
Author(s)
Luo, Ying
Kobler, James B
Heaton, James T
Jia, Xinqiao
Zeitels, Steven M
Langer, Robert
Date Issued
2010
Journal
Journal of Biomedical Materials Research - Part B Applied Biomaterials
Publisher
Wiley
Citation
Luo, Y., et al. "Injectable Hyaluronic Acid-Dextran Hydrogels and Effects of Implantation in Ferret Vocal Fold." Journal of Biomedical Materials Research Part B-Applied Biomaterials 93B 2 (2010): 386-93.
Version
Author's final manuscript
Abstract
Injectable hydrogels may potentially be used for augmentation/regeneration of the lamina propria of vocal fold tissue. In this study, hyaluronic acid (HA) and dextran were chemically modified and subsequently crosslinked via formation of hydrazone bonds in phosphate buffer. Swelling ratios, degradation, and compressive moduli of the resulting hydrogels were investigated. It was found that the properties of HA-dextran hydrogels were variable and the trend of variation could be correlated with the hydrogel composition. The biocompatibility of three injectable HA-dextran hydrogels with different crosslinking density was assessed in the vocal fold region using a ferret model. It was found that HA-dextran hydrogels implanted for three weeks stimulated mild foreignbody reactions. Distinct tissue-material interactions were also observed for hydrogels made from different formulations: the hydrogel with the lowest crosslinking density was completely degraded in vivo; while material residues were visible for other types of hydrogel injections, with or without cell penetration into the implantation depending on the hydrogel composition. The in vivo results suggest that the HA-dextran hydrogel matrices can be further developed for applications of vocal fold tissue restoration. © 2010 Wiley Periodicals, Inc.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/jbm.b.31593
