Learning substrates in the primate prefrontal cortex and striatum: sustained activity related to successful actions
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Histed_Learning substrates.pdf
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2.74 MB
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Author(s)
Histed, Mark H.
Pasupathy, Anitha
Miller, Earl K.
Date Issued
July 2009
Journal
Neuron
Publisher
Elsevier Inc.
Citation
Histed M.H., Pasupathy A., Miller E.K. Learning Substrates in the Primate Prefrontal Cortex and Striatum: Sustained Activity Related to Successful Actions (2009) Neuron, 63 (2), pp. 244-253.
Version
Author's final manuscript
Abstract
Learning from experience requires knowing whether a past action resulted in a desired outcome. The prefrontal cortex and basal ganglia are thought to play key roles in such learning of arbitrary stimulus-response associations. Previous studies have found neural activity in these areas, similar to dopaminergic neurons' signals, that transiently reflect whether a response is correct or incorrect. However, it is unclear how this transient activity, which fades in under a second, influences actions that occur much later. Here, we report that single neurons in both areas show sustained, persistent outcome-related responses. Moreover, single behavioral outcomes influence future neural activity and behavior: behavioral responses are more often correct and single neurons more accurately discriminate between the possible responses when the previous response was correct. These long-lasting signals about trial outcome provide a way to link one action to the next and may allow reward signals to be combined over time to implement successful learning.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
http://dx.doi.org/10.1016/j.neuron.2009.06.019
