Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Name
Fujimoto-Split-spectrum amplitude.pdf
Size
6.43 MB
Format
Adobe PDF
Checksum (MD5)
39de214a1a5ffa53978b4a8152961529
Author(s)
Jia, Yali
Tan, Ou
Tokayer, Jason
Potsaid, Benjamin M.
Wang, Yimin
Liu, Jonathan Jaoshin
Kraus, Martin Franz Georg
Subhash, Hrebesh
Hornegger, Joachim
Huang, David
Date Issued
February 2012
Journal
Optics Express
Publisher
Optical Society of America
Citation
Jia, Yali et al. “Split-spectrum Amplitude-decorrelation Angiography with Optical Coherence Tomography.” Optics Express 20.4 (2012): 4710.
Version
Author's final manuscript
Abstract
Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
MIT Kavli Institute for Astrophysics and Space Research
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1364/oe.20.004710
