Clinical viability of magnetic bead implants in muscle
Name
fbioe-10-1010276.pdf
Size
2.09 MB
Format
Adobe PDF
Checksum (MD5)
c9ddc956f6ea2ff8b85836fa3252d2aa
Author(s)
Taylor, Cameron R.
Clark, William H.
Clarrissimeaux, Ellen G.
Yeon, Seong Ho
Carty, Matthew J.
Lipsitz, Stuart R.
Bronson, Roderick T.
Roberts, Thomas J.
Herr, Hugh M.
Date Issued
October 25, 2022
Publisher
Frontiers Media SA
Citation
Taylor, Cameron R., Clark, William H., Clarrissimeaux, Ellen G., Yeon, Seong Ho, Carty, Matthew J. et al. 2022. "Clinical viability of magnetic bead implants in muscle." 10.
Version
Final published version
Abstract
Human movement is accomplished through muscle contraction, yet there does not exist a portable system capable of monitoring muscle length changes in real time. To address this limitation, we previously introduced magnetomicrometry, a minimally-invasive tracking technique comprising two implanted magnetic beads in muscle and a magnetic field sensor array positioned on the body’s surface adjacent the implanted beads. The implant system comprises a pair of spherical magnetic beads, each with a first coating of nickel-copper-nickel and an outer coating of Parylene C. In parallel work, we demonstrate submillimeter accuracy of magnetic bead tracking for muscle contractions in an untethered freely-roaming avian model. Here, we address the clinical viability of magnetomicrometry. Using a specialized device to insert magnetic beads into muscle in avian and lagomorph models, we collect data to assess gait metrics, bead migration, and bead biocompatibility. For these animal models, we find no gait differences post-versus pre-implantation, and bead migration towards one another within muscle does not occur for initial bead separation distances greater than 3 cm. Further, using extensive biocompatibility testing, the implants are shown to be non-irritant, non-cytotoxic, non-allergenic, and non-irritating. Our cumulative results lend support for the viability of these magnetic bead implants for implantation in human muscle. We thus anticipate their imminent use in human-machine interfaces, such as in control of prostheses and exoskeletons and in closed-loop neuroprosthetics to aid recovery from neurological disorders.
Subjects
Biomedical Engineering
Histology
Bioengineering
Biotechnology
MIT Department
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fbioe.2022.1010276
