Evaluation of layer-by-layer assembly of polyelectrolyte multilayers in cell patterning technology
Name
50632739-MIT.pdf
Description
Full printable version
Size
4.64 MB
Format
Adobe PDF
Checksum (MD5)
a91506c98ddc56bb9a4461a3f55b93b1
Author(s)
White, Aleksandr John, 1976-
Advisor(s)
Michael F. Rubner.
Date Issued
2002
Publisher
Massachusetts Institute of Technology
Abstract
The layer-by-layer assembly of polyelectrolytes into multilayered films is an attractive approach for fabricating novel biomaterials, as it offers tremendous control over the internal composition and surface properties of their layered architectures. In this work, polyelectrolyte multilayers (PEMs) were evaluated as a platform for applications in controlling the spatial adhesion of living cells. An overview is presented on current developments and competing technologies within research and industry with respect to cell patterning and cell-based devices. Interviewed individuals in research and industry suggested a variety of potential applications of PEMs in cell patterning technology. A patent search on the core technologies (i.e. PEMs and patterning methods) and on applications in cell patterning, cell-based screening, and cell-based biosensors revealed ample opportunity for starting a new venture with a platform based on the layer-by-layer assembly of PEMs. A brief business plan for starting a new venture with a platform based on the layer-by-layer assembly of PEMs is proposed to initially target the high throughput screening and cell-based biosensor markets.
Description
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2002.
Includes bibliographical references (p. 45-49).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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