Cartilage diseases
Name
Grodzinsky_Cartilage diseases.pdf
Description
Accepted version
Size
1.33 MB
Format
Adobe PDF
Checksum (MD5)
7179398f09c26e02b8b54ee47b48a6e9
Author(s)
Krishnan, Yamini
Grodzinsky, Alan J.
Date Issued
October 2018
Journal
Matrix Biology
Publisher
Elsevier BV
Citation
Krishnan, Yamini and Alan J. Grodzinsky. "Cartilage diseases." Matrix Biology, 71-72 (October 2018):p.51-69. © 2018 Elsevier BV.
Version
Author's final manuscript
Abstract
Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth. The structure and organization of cartilage's extracellular matrix (ECM) are the primary determinants of normal function. Most diseases involving cartilage lead to dramatic changes in the ECM which can govern disease progression (e.g., in osteoarthritis), cause the main symptoms of the disease (e.g., dwarfism caused by genetically inherited mutations) or occur as collateral damage in pathological processes occurring in other nearby tissues (e.g., osteochondritis dissecans and inflammatory arthropathies). Challenges associated with cartilage diseases include poor understanding of the etiology and pathogenesis, delayed diagnoses due to the aneural nature of the tissue and drug delivery challenges due to the avascular nature of adult cartilages. This narrative review provides an overview of the clinical and pathological features as well as current treatment options available for various cartilage diseases. Late breaking advances are also described in the quest for development and delivery of effective disease modifying drugs for cartilage diseases including osteoarthritis, the most common form of arthritis that affects hundreds of millions of people worldwide. Keywords: Extracellular matrix, Cartilage, Diseases of cartilage, Growth plate fractures, Genetic disorders involving cartilage, Osteochondritis dissecans, Relapsing polychondritis, Chondrocalcinosis, Pseudogout cartilaginous tumors, Inflammatory arthropathies, OsteoarthritisPost-traumatic osteoarthritis, Cartilage ECM-targeted drug carriers
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.MATBIO.2018.05.005
