Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity
Name
Tsai-Alternative functions.pdf
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1.24 MB
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Adobe PDF
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3ca2ebabec6373a58f703d2797c803af
Author(s)
Frank, Christopher Lee
Tsai, Li-Huei
Date Issued
May 2009
Journal
Neuron
Publisher
Elsevier
Citation
Frank, Christopher L., and Li-Huei Tsai. “Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity.” Neuron 62.3 (2009): 312–326. Web. 27 Apr. 2012. © 2009 Elsevier Inc.
Version
Author's final manuscript
Abstract
Recent studies have demonstrated that boundaries separating a cycling cell from a postmitotic neuron are not as concrete as expected. Novel and unique physiological functions in neurons have been ascribed for proteins fundamentally required for cell cycle progression and control. These “core” cell cycle regulators serve diverse postmitotic functions that span various developmental stages of a neuron, including neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis, and synaptic maturation and plasticity. In this review, we detail the nonproliferative postmitotic roles that these cell cycle proteins have recently been reported to play, the significance of their expression in neurons, mechanistic insight when available, and future prospects.
MIT Department
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2009.03.029
