Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making
Name
nihms917804.pdf
Description
Accepted version
Size
4.83 MB
Format
Adobe PDF
Checksum (MD5)
f1262abf952fab996683656bdc86c667
Author(s)
Friedman, Alexander
Homma, Daigo
Bloem, Bernard
Gibb, Leif G.
Amemori, Ken-ichi
Hu, Dan
Delcasso, Sebastien
Truong, Timothy F.
Yang, Joyce C
Hood, Adam S.
Date Issued
November 2017
Journal
Cell
Publisher
Elsevier BV
Citation
Friedman, Alexander et al. "Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making." Cell 171, 5 (November 2017): P1191-1205.e28 © 2017 Elsevier
Version
Author's final manuscript
Abstract
Effective evaluation of costs and benefits is a core survival capacity that in humans is considered as optimal, “rational” decision-making. This capacity is vulnerable in neuropsychiatric disorders and in the aftermath of chronic stress, in which aberrant choices and high-risk behaviors occur. We report that chronic stress exposure in rodents produces abnormal evaluation of costs and benefits resembling non-optimal decision-making in which choices of high-cost/high-reward options are sharply increased. Concomitantly, alterations in the task-related spike activity of medial prefrontal neurons correspond with increased activity of their striosome-predominant striatal projection neuron targets and with decreased and delayed striatal fast-firing interneuron activity. These effects of chronic stress on prefronto-striatal circuit dynamics could be blocked or be mimicked by selective optogenetic manipulation of these circuits. We suggest that altered excitation-inhibition dynamics of striosome-based circuit function could be an underlying mechanism by which chronic stress contributes to disorders characterized by aberrant decision-making under conflict.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2017.10.017
